Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8RCK
DownloadVisualize
BU of 8rck by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused on one protomer copy.
To Be Published
8RCN
DownloadVisualize
BU of 8rcn by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, Focused region of mTOR and RAPTOR on one protomer copy.
To Be Published
8RCH
DownloadVisualize
BU of 8rch by Molmil
CryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in mTOR, overall refinement
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Anandapadamanaban, M, Hay, I.M, Perisic, O, Williams, R.L.
Deposit date:2023-12-06
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (4 Å)
Cite:cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement
To Be Published
8KF6
DownloadVisualize
BU of 8kf6 by Molmil
The cryo-EM structure of AV-45 bound type3 amyloid beta 42 fibril.
Descriptor: P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
8KF5
DownloadVisualize
BU of 8kf5 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril in AD3.
To Be Published
8KF3
DownloadVisualize
BU of 8kf3 by Molmil
The cryo-EM structure of type3 amyloid beta 42 fibril.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
8KF4
DownloadVisualize
BU of 8kf4 by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
Descriptor: Amyloid-beta precursor protein
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril in AD2 patient.
To Be Published
8KF1
DownloadVisualize
BU of 8kf1 by Molmil
The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
Descriptor: 4-[2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethyl]-~{N}-methyl-aniline, P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-15
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The cryo-EM structure of AV-45 bound type1 amyloid beta 42 fibril.
To Be Published
8KEW
DownloadVisualize
BU of 8kew by Molmil
The cryo-EM structure of type1 amyloid beta 42 fibril.
Descriptor: P3(40)
Authors:Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D.
Deposit date:2023-08-13
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The cryo-EM structure of type1 amyloid beta 42 fibril.
To Be Published
8PT5
DownloadVisualize
BU of 8pt5 by Molmil
ERK2 covelently bound to RU187 cyclohexenone based inhibitor
Descriptor: GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Sok, P, Poti, A, Remenyi, A.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PSY
DownloadVisualize
BU of 8psy by Molmil
ERK2 covelently bound to RU68 cyclohexenone based inhibitor
Descriptor: AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{R})-4-oxidanylidene-1-(phenylmethyl)cyclohexane-1,3-dicarboxylate
Authors:Sok, P, Poti, A, Remenyi, A, Gogl, G.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PSW
DownloadVisualize
BU of 8psw by Molmil
ERK2 covalently bound to RU67 cyclohexenone based inhibitor
Descriptor: AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{R})-4-oxidanylidene-1-(phenylmethyl)cyclohexane-1,3-dicarboxylate
Authors:Sok, P, Poti, A, Remenyi, A, Gogl, G.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PT1
DownloadVisualize
BU of 8pt1 by Molmil
ERK2 covelently bound to RU76 cyclohexenone based inhibitor
Descriptor: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{O}1-methyl ~{O}3-(phenylmethyl) (1~{S},3~{R})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate
Authors:Sok, P, Poti, A, Remenyi, A, Gogl, G.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PT3
DownloadVisualize
BU of 8pt3 by Molmil
ERK2 covelently bound to RU77 cyclohexenone based inhibitor
Descriptor: GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Sok, P, Poti, A, Remenyi, A.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PST
DownloadVisualize
BU of 8pst by Molmil
ERK2 covelently bound to RU60 cyclohexenone based inhibitor
Descriptor: AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{S})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate
Authors:Sok, P, Poti, A, Remenyi, A, Gogl, G.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PSR
DownloadVisualize
BU of 8psr by Molmil
ERK2 covalently bound to SynthRevD-12-opt artificial peptide
Descriptor: GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Sok, P, Poti, A, Gogl, G, Remenyi, A.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8PT0
DownloadVisualize
BU of 8pt0 by Molmil
ERK2 covelently bound to RU75 cyclohexenone based inhibitor
Descriptor: GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Sok, P, Poti, A, Remenyi, A, Gogl, G.
Deposit date:2023-07-13
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
8T1L
DownloadVisualize
BU of 8t1l by Molmil
Atomic model of the mammalian mouse Mediator complex with CKM module
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-02
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (4.83 Å)
Cite:A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
To Be Published
8T9D
DownloadVisualize
BU of 8t9d by Molmil
CryoEM structure of TR-TRAP
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-23
Release date:2024-07-03
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (4.66 Å)
Cite:An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
8T1I
DownloadVisualize
BU of 8t1i by Molmil
Atomic model of the mammalian Mediator complex with MED26 subunit
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-02
Release date:2024-06-12
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (4.68 Å)
Cite:An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
8ZJV
DownloadVisualize
BU of 8zjv by Molmil
Crystal Structure of the ERK2 complexed with 5-Iodotubercidin
Descriptor: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Yang, Y, Fu, L, Chen, R, Cheng, H, Sun, X.
Deposit date:2024-05-15
Release date:2024-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the ERK2 complexed with 5-Iodotubercidin
To Be Published
8SNL
DownloadVisualize
BU of 8snl by Molmil
Structure of human ADAM17/iRhom2 sheddase complex
Descriptor: CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2, ...
Authors:Zhao, H, Dai, Y, Wang, Y, Lee, C.H.
Deposit date:2023-04-27
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Structure of human ADAM17/iRhom2 sheddase complex
To Be Published
8SNM
DownloadVisualize
BU of 8snm by Molmil
Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
Descriptor: CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Disintegrin and metalloproteinase domain-containing protein 17 propeptide, ...
Authors:Zhao, H, Dai, Y, Wang, Y, Lee, C.H.
Deposit date:2023-04-27
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
To Be Published
8VXE
DownloadVisualize
BU of 8vxe by Molmil
Structure of p38 alpha (Mitogen-activated protein kinase 14) complexed with inhibitor 6
Descriptor: (4M)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 14
Authors:Blaesse, M, Steinbacher, S, Shaffer, P.L, Sharma, S, Thompson, A.A.
Deposit date:2024-02-04
Release date:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions.
Acs Med.Chem.Lett., 15, 2024
9AXY
DownloadVisualize
BU of 9axy by Molmil
Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon