8PSW
ERK2 covalently bound to RU67 cyclohexenone based inhibitor
Summary for 8PSW
Entry DOI | 10.2210/pdb8psw/pdb |
Descriptor | Mitogen-activated protein kinase 1, AMP PHOSPHORAMIDATE, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{R})-4-oxidanylidene-1-(phenylmethyl)cyclohexane-1,3-dicarboxylate, ... (4 entities in total) |
Functional Keywords | mapk kinase, mapk, inhibitor, covalent, erk2, michael acceptor warhead, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42519.57 |
Authors | |
Primary citation | Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D. Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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