8PT5

ERK2 covelently bound to RU187 cyclohexenone based inhibitor

Summary for 8PT5

• Entry DOI: 10.2210/pdb8pt5/pdb
• Descriptor: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{R})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate, ... (5 entities in total)
• Functional Keywords: mapk kinase, mapk, inhibitor, covalent, erk2, signaling protein, michael acceptor warhead
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42615.55

Authors

Sok, P.,Poti, A.,Remenyi, A. (deposition date: 2023-07-13, release date: 2024-07-24)

• Primary citation: Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)