8PT3

ERK2 covelently bound to RU77 cyclohexenone based inhibitor

Summary for 8PT3

• Entry DOI: 10.2210/pdb8pt3/pdb
• Descriptor: Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{S},5~{R})-6-methylidene-4-oxidanylidene-bicyclo[3.2.1]octane-1,3-dicarboxylate, GLYCEROL, ... (5 entities in total)
• Functional Keywords: mapk kinase, mapk, inhibitor, covalent, erk2, signaling protein, michael acceptor warhead
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42823.76

Authors

Sok, P.,Poti, A.,Remenyi, A. (deposition date: 2023-07-13, release date: 2024-07-24)

• Primary citation: Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)