8PT1
ERK2 covelently bound to RU76 cyclohexenone based inhibitor
Summary for 8PT1
Entry DOI | 10.2210/pdb8pt1/pdb |
Descriptor | Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{O}1-methyl ~{O}3-(phenylmethyl) (1~{S},3~{R})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate, ... (4 entities in total) |
Functional Keywords | mapk kinase, mapk, inhibitor, covalent, erk2, michael acceptor warhead, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42557.48 |
Authors | |
Primary citation | Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D. Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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