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5XWT
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BU of 5xwt by Molmil
Crystal structure of PTPdelta Ig1-Fn1 in complex with SALM5 LRR-Ig
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2017-06-30
Release date:2018-06-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.178 Å)
Cite:Structural basis of trans-synaptic interactions between PTP delta and SALMs for inducing synapse formation.
Nat Commun, 9, 2018
5FM5
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BU of 5fm5 by Molmil
Crystal structure of the myomesin:obscurin-like-1 complex
Descriptor: MYOMESIN-1, OBSCURIN-LIKE-1
Authors:Pernigo, S, Steiner, R.A.
Deposit date:2015-11-01
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.
Structure, 25, 2017
2XYC
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BU of 2xyc by Molmil
CRYSTAL STRUCTURE OF NCAM2 IGIV-FN3I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NEURAL CELL ADHESION MOLECULE 2, ...
Authors:Kulahin, N, Rasmussen, K.K, Kristensen, O, Berezin, V, Bock, E, Walmod, P.S, Gajhede, M.
Deposit date:2010-11-17
Release date:2011-02-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Model and Trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule.
Structure, 19, 2011
8QY4
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BU of 8qy4 by Molmil
Structure of interleukin 11 (gp130 P496L mutant).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
8QY5
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BU of 8qy5 by Molmil
Structure of interleukin 6.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
8QY6
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BU of 8qy6 by Molmil
Structure of interleukin 6 (gp130 P496L mutant).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency.
Nat Commun, 15, 2024
6P67
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BU of 6p67 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-06-03
Release date:2019-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6P50
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BU of 6p50 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-05-29
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6POL
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BU of 6pol by Molmil
Crystal structure of the human NELL1 EGF1-3-Robo3 FN1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
Authors:Wang, J, Pak, J.S, Ozkan, E.
Deposit date:2019-07-04
Release date:2020-05-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun, 11, 2020
3UP1
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BU of 3up1 by Molmil
Crystal structure of the unliganded human interleukin-7 receptor extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:McElroy, C.A, Holland, P.J, Walsh, S.T.R.
Deposit date:2011-11-17
Release date:2012-02-08
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural reorganization of the interleukin-7 signaling complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UTO
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BU of 3uto by Molmil
Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26)
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ...
Authors:Castelmur, E, Barbieri, S, Mayans, O.
Deposit date:2011-11-26
Release date:2012-08-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.
Proc.Natl.Acad.Sci.USA, 109, 2012
6CE9
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BU of 6ce9 by Molmil
Insulin Receptor ectodomain in complex with two insulin molecules
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6CEB
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BU of 6ceb by Molmil
Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6POG
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BU of 6pog by Molmil
Crystal structure of the NELL2 EGF1-6-Robo3 FN1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, J, Pak, J.S, Ozkan, E.
Deposit date:2019-07-03
Release date:2020-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Nat Commun, 11, 2020
6CE7
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BU of 6ce7 by Molmil
Insulin Receptor ectodomain in complex with one insulin molecule
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6PXV
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BU of 6pxv by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region.
Descriptor: Insulin, Insulin receptor
Authors:Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
Deposit date:2019-07-27
Release date:2019-09-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
6YGN
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BU of 6ygn by Molmil
Titin kinase and its flanking domains
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Titin
Authors:Fleming, J.R, Franke, B, Bogomolovas, J, Mayans, O.
Deposit date:2020-03-27
Release date:2021-04-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.
Embo Rep., 22, 2021
6PXW
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BU of 6pxw by Molmil
Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex.
Descriptor: Insulin, Insulin receptor
Authors:Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C.
Deposit date:2019-07-28
Release date:2019-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
Elife, 8, 2019
6BRB
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BU of 6brb by Molmil
Novel non-antibody protein scaffold targeting CD40L
Descriptor: CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019
6ZZ8
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BU of 6zz8 by Molmil
MB_CRS6-15 bound to CrSAS-6_6HR
Descriptor: Centriole protein, Protein B
Authors:Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P.
Deposit date:2020-08-04
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
6SOF
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BU of 6sof by Molmil
human insulin receptor ectodomain bound by 4 insulin
Descriptor: Insulin, Insulin receptor
Authors:Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U.
Deposit date:2019-08-29
Release date:2019-11-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain.
J.Cell Biol., 219, 2020
7PG2
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BU of 7pg2 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG0
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BU of 7pg0 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG4
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BU of 7pg4 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG3
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BU of 7pg3 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2
Descriptor: Insulin, Isoform Short of Insulin receptor
Authors:Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
Deposit date:2021-08-12
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022

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