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3ZU1
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BU of 3zu1 by Molmil
Structure of LysB29(Nepsilon omega-carboxyheptadecanoyl) des(B30) Human Insulin
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Schluckebier, G, Whittingham, J.
Deposit date:2011-07-13
Release date:2011-08-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Lysb29(Nepsilon Omega-Carboxyheptadecanoyl) Des(B30) Human Insulin
To be Published
6S4I
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BU of 6s4i by Molmil
Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin
Descriptor: Insulin, NITRATE ION
Authors:Johansson, E.
Deposit date:2019-06-28
Release date:2020-07-15
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (1.511 Å)
Cite:Molecular engineering of safe and efficacious oral basal insulin.
Nat Commun, 11, 2020
6RVA
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BU of 6rva by Molmil
STRUCTURE OF [ASP58]-IGF-I ANALOGUE
Descriptor: Insulin-like growth factor I
Authors:Jiracek, J, Zakova, L, Socha, O.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses.
J.Biol.Chem., 294, 2019
4BS3
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BU of 4bs3 by Molmil
Bovin insulin structure determined by in situ crystal analysis and sulfur-SAD phasing at room temperature
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN
Authors:Pinker, F, Stirnimann, C, Sauter, C, Olieric, V.
Deposit date:2013-06-06
Release date:2013-07-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Chipx: A Novel Microfluidic Chip for Counter- Diffusion Crystallization of Biomolecules and in Situ Crystal Analysis at Room Temperature
J.Cryst.Growth, 13, 2013
3ZS2
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BU of 3zs2 by Molmil
TyrB25,NMePheB26,LysB28,ProB29-insulin analogue crystal structure
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A.
Deposit date:2011-06-21
Release date:2011-08-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
J.Biol.Chem., 286, 2011
1ZEG
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BU of 1zeg by Molmil
STRUCTURE OF B28 ASP INSULIN IN COMPLEX WITH PHENOL
Descriptor: CHLORIDE ION, INSULIN, PHENOL, ...
Authors:Whittingham, J.L, Edwards, E.J, Antson, A.A, Clarkson, J.M, Dodson, G.G.
Deposit date:1998-05-01
Release date:1998-07-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.
Biochemistry, 37, 1998
1ZNJ
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BU of 1znj by Molmil
INSULIN, MONOCLINIC CRYSTAL FORM
Descriptor: CHLORIDE ION, INSULIN, PHENOL, ...
Authors:Turkenburg, M.G.W, Whittingham, J.L, Turkenburg, J.P, Dodson, G.G, Derewenda, U, Smith, G.D, Dodson, E.J, Derewenda, Z.S, Xiao, B.
Deposit date:1997-09-23
Release date:1998-01-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure Determination and Refinement of Two Crystal Forms of Native Insulins
To be Published
1XDA
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BU of 1xda by Molmil
STRUCTURE OF INSULIN
Descriptor: CHLORIDE ION, FATTY ACID ACYLATED INSULIN, MYRISTIC ACID, ...
Authors:Whittingham, J.L, Havelund, S, Jonassen, I.
Deposit date:1996-12-18
Release date:1997-07-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a prolonged-acting insulin with albumin-binding properties.
Biochemistry, 36, 1997
1ZEH
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BU of 1zeh by Molmil
STRUCTURE OF INSULIN
Descriptor: CHLORIDE ION, INSULIN, M-CRESOL, ...
Authors:Whittingham, J.L, Edwards, E.J, Antson, A.A, Clarkson, J.M, Dodson, G.G.
Deposit date:1998-05-01
Release date:1998-12-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues.
Biochemistry, 37, 1998
1XW7
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BU of 1xw7 by Molmil
Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z.L, Huang, K, Xu, B, Chu, Y.C, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2004-10-29
Release date:2005-04-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
1XGL
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BU of 1xgl by Molmil
HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES
Descriptor: INSULIN
Authors:Hua, Q.X, Gozani, S.N, Chance, R.E, Hoffmann, J.A, Frank, B.H, Weiss, M.A.
Deposit date:1996-10-10
Release date:1997-04-01
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
1SJT
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BU of 1sjt by Molmil
MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
Descriptor: PROINSULIN
Authors:Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
5CO9
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BU of 5co9 by Molmil
Crystal structure of human zinc insulin at pH 6.5
Descriptor: CHLORIDE ION, Insulin, ZINC ION
Authors:Lima, L.M.T.R, Palmieri, L.C.
Deposit date:2015-07-20
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of human zinc insulin at pH 6.5
To Be Published
5CO6
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BU of 5co6 by Molmil
Crystal structure of human zinc insulin at pH 6.5
Descriptor: CHLORIDE ION, Insulin, MAGNESIUM ION, ...
Authors:Lima, L.M.T.R, PALMIERI, L.C.
Deposit date:2015-07-19
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human zinc insulin at pH 6.5
To Be Published
5E7W
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BU of 5e7w by Molmil
X-ray Structure of Human Recombinant 2Zn insulin at 0.92 Angstrom
Descriptor: ACETATE ION, Insulin, N-PROPANOL, ...
Authors:Lisgarten, D.R, Naylor, C.E, Palmer, R.A, Lobley, C.M.C.
Deposit date:2015-10-13
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (0.9519 Å)
Cite:Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K.
Chem Cent J, 11, 2017
1T1K
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BU of 1t1k by Molmil
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor: Insulin
Authors:Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
5D53
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BU of 5d53 by Molmil
In meso in situ serial X-ray crystallography structure of insulin at 100 K
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Insulin A chain, Insulin B chain, ...
Authors:Huang, C.-Y, Olieric, V, Diederichs, K, Wang, M, Caffrey, M.
Deposit date:2015-08-10
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
1RWE
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BU of 1rwe by Molmil
Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
5ENA
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BU of 5ena by Molmil
Xray crystal structure of isotope-labeled human insulin
Descriptor: Insulin chain A, Insulin chain B
Authors:Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H.
Deposit date:2015-11-09
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
5D52
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BU of 5d52 by Molmil
In meso in situ serial X-ray crystallography structure of insulin at room temperature
Descriptor: Insulin A chain, Insulin B chain, PHOSPHATE ION
Authors:Huang, C.-Y, Olieric, V, Warshamanage, R, Diederichs, K, Wang, M, Caffrey, M.
Deposit date:2015-08-10
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
5D54
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BU of 5d54 by Molmil
In meso X-ray crystallography structure of insulin at 100 K
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Insulin A chain, Insulin B chain, ...
Authors:Huang, C.-Y, Olieric, V, Wang, M, Caffrey, M.
Deposit date:2015-08-10
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
5D5E
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BU of 5d5e by Molmil
In meso in situ serial X-ray crystallography structure of insulin by sulfur-SAD at 100 K
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Insulin A chain, Insulin B chain, ...
Authors:Huang, C.-Y, Olieric, V, Warshamanage, R, Diederichs, K, Wang, M, Caffrey, M.
Deposit date:2015-08-10
Release date:2016-01-13
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.407 Å)
Cite:In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
Acta Crystallogr D Struct Biol, 72, 2016
5EN9
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BU of 5en9 by Molmil
High resolution x-ray crystal structure of isotope-labeled ester-insulin
Descriptor: Insulin chain A, Insulin chain B
Authors:Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H.
Deposit date:2015-11-09
Release date:2016-01-13
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
1TRZ
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BU of 1trz by Molmil
CRYSTALLOGRAPHIC EVIDENCE FOR DUAL COORDINATION AROUND ZINC IN THE T3R3 HUMAN INSULIN HEXAMER
Descriptor: CHLORIDE ION, INSULIN, SODIUM ION, ...
Authors:Ciszak, E, Smith, G.D.
Deposit date:1993-11-19
Release date:1994-01-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic evidence for dual coordination around zinc in the T3R3 human insulin hexamer.
Biochemistry, 33, 1994
1TYL
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BU of 1tyl by Molmil
THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE
Descriptor: CHLORIDE ION, INSULIN, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ...
Authors:Smith, G.D, Ciszak, E.
Deposit date:1994-06-21
Release date:1994-09-30
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of a complex of hexameric insulin and 4'-hydroxyacetanilide.
Proc.Natl.Acad.Sci.USA, 91, 1994

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