PDB: 296 resultsInfo pagesStatus searchChemie searchBIRD

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4E4V	The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Importin subunit alpha-2 Authors: Hang, P.C, Miknis, Z.M, Franke, W.A, Umland, T.C, Schultz, L.W. Deposit date: 2012-03-13 Release date: 2013-05-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5283 Å) Cite: The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. To be Published
3OQS	Crystal structure of importin-alpha bound to a CLIC4 NLS peptide Descriptor: Importin subunit alpha-2, peptide of Chloride intracellular channel protein 4 Authors: Mynott, A.V, Brown, L.J, Harrop, S.J, Curmi, P.M.G. Deposit date: 2010-09-03 Release date: 2011-07-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 Febs J., 278, 2011
3NMW	Crystal structure of armadillo repeats domain of APC Descriptor: APC variant protein, SULFATE ION Authors: Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. Deposit date: 2010-06-22 Release date: 2011-07-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
3Q5U	A minimal NLS from human scramblase 4 complexed with importin alpha Descriptor: Importin subunit alpha-2, Phospholipid scramblase 4 Authors: Bhardwaj, A, Cingolani, G. Deposit date: 2010-12-29 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin {alpha}1. J.Biol.Chem., 286, 2011
3QHE	Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68 Descriptor: Adenomatous polyposis coli protein, KH domain-containing, RNA-binding, ... Authors: Morishita, E.C.J, Murayama, K, Kato-Murayama, M, Ishizuku-Katsura, Y, Tomabechi, Y, Terada, T, Handa, N, Shirouzu, M, Akiyama, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-01-25 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68 Structure, 19, 2011
3NMX	Crystal structure of APC complexed with Asef Descriptor: APC variant protein, Rho guanine nucleotide exchange factor 4 Authors: Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. Deposit date: 2010-06-22 Release date: 2011-07-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
8GSJ	APC-Asef tripeptide inhibitor Descriptor: (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ... Authors: Zhang, J, Wang, X.F, Song, K. Deposit date: 2022-09-06 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: APC-Asef tripeptide inhibitor To Be Published
5H2X	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172) Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1 Authors: Hirano, H, Matsuura, Y. Deposit date: 2016-10-18 Release date: 2016-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
8G8R	RelB NLS in complex with Importin alpha 2 Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Transcription factor RelB Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: monopartite p52 NLS in complex with Importin alpha 2 To Be Published
8G8S	bipartite p52 NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p100 subunit isoform X1 Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: p52 bipartite NLS in complex with Importin alpha 2 To Be Published
8G8Q	RelB NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, bacterial peptide, monopartite p52 NLS Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: p52 monopartite NLS in complex with Importin alpha 2 To Be Published
8GCN	CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER Descriptor: Importin subunit alpha-1, Importin subunit beta-1 Authors: Ko, Y, Cingolani, G. Deposit date: 2023-03-02 Release date: 2024-03-06 Last modified: 2024-09-18 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Sci Adv, 10, 2024
5H43	Structural and mechanistical studies of the nuclear import by Importin-alpha Descriptor: Histone acetyltransferase KAT8, Importin subunit alpha-1 Authors: Wang, R, Li, Y. Deposit date: 2016-10-28 Release date: 2017-10-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1 Traffic, 19, 2018
5H2W	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340) Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1 Authors: Hirano, H, Matsuura, Y. Deposit date: 2016-10-18 Release date: 2016-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
8HKW	Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1 Authors: Matsuura, Y. Deposit date: 2022-11-28 Release date: 2022-12-21 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data Brief, 47, 2023
5GXW	Importin and NuMA complex Descriptor: Importin subunit alpha-1, Peptide from Nuclear mitotic apparatus protein 1 Authors: Chang, C.-C, Huang, T.-L, Hsia, K.-C. Deposit date: 2016-09-20 Release date: 2017-10-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.394 Å) Cite: Regulation of mitotic spindle assembly factor NuMA by Importin-beta J. Cell Biol., 216, 2017
8HE3	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751) Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1, SULFATE ION Authors: Matsuura, Y. Deposit date: 2022-11-07 Release date: 2023-02-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
8HE0	Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type) Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1 Authors: Matsuura, Y. Deposit date: 2022-11-07 Release date: 2023-02-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha. Biochem.Biophys.Res.Commun., 652, 2023
5HHG	Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 Authors: Smith, K.M, Forwood, J.K. Deposit date: 2016-01-11 Release date: 2016-05-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
8Y0P	Beta-Catenin in complex with peptide 301 Descriptor: B-cell CLL/lymphoma 9 protein, Catenin beta-1, PROLINE Authors: Tim, F. Deposit date: 2024-01-22 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Beta-Catenin in complex with peptide 301 To Be Published
5HUY	Structure of HCMV Small Terminase NLS bound to importin alpha Descriptor: HCMV small terminase, Importin subunit alpha-1 Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2016-01-28 Release date: 2016-03-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.979 Å) Cite: Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
1IAL	IMPORTIN ALPHA, MOUSE Descriptor: IMPORTIN ALPHA Authors: Kobe, B. Deposit date: 1999-01-12 Release date: 1999-06-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat.Struct.Biol., 6, 1999
5HUW	Structure of HSV-1 Large Terminase NLS bound to importin alpha Descriptor: HSV1 large terminase NLS, Importin subunit alpha-1 Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2016-01-27 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
1I7X	BETA-CATENIN/E-CADHERIN COMPLEX Descriptor: BETA-CATENIN, EPITHELIAL-CADHERIN Authors: Huber, A.H, Weis, W.I. Deposit date: 2001-03-10 Release date: 2001-05-16 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell(Cambridge,Mass.), 105, 2001
8VPU	Crystal structure of mouse Importin alpha in complex with dengue virus 3 NS5 central NLS peptide Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide Authors: Roman, N, Swarbrick, C.M.D, Forwood, J.K. Deposit date: 2024-01-17 Release date: 2024-08-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. Acs Infect Dis., 10, 2024

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