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4E4V
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BU of 4e4v by Molmil
The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Importin subunit alpha-2
Authors:Hang, P.C, Miknis, Z.M, Franke, W.A, Umland, T.C, Schultz, L.W.
Deposit date:2012-03-13
Release date:2013-05-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5283 Å)
Cite:The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
To be Published
3OQS
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BU of 3oqs by Molmil
Crystal structure of importin-alpha bound to a CLIC4 NLS peptide
Descriptor: Importin subunit alpha-2, peptide of Chloride intracellular channel protein 4
Authors:Mynott, A.V, Brown, L.J, Harrop, S.J, Curmi, P.M.G.
Deposit date:2010-09-03
Release date:2011-07-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4
Febs J., 278, 2011
3NMW
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BU of 3nmw by Molmil
Crystal structure of armadillo repeats domain of APC
Descriptor: APC variant protein, SULFATE ION
Authors:Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
Deposit date:2010-06-22
Release date:2011-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
3Q5U
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BU of 3q5u by Molmil
A minimal NLS from human scramblase 4 complexed with importin alpha
Descriptor: Importin subunit alpha-2, Phospholipid scramblase 4
Authors:Bhardwaj, A, Cingolani, G.
Deposit date:2010-12-29
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Minimal Nuclear Localization Signal (NLS) in Human Phospholipid Scramblase 4 That Binds Only the Minor NLS-binding Site of Importin {alpha}1.
J.Biol.Chem., 286, 2011
3QHE
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BU of 3qhe by Molmil
Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68
Descriptor: Adenomatous polyposis coli protein, KH domain-containing, RNA-binding, ...
Authors:Morishita, E.C.J, Murayama, K, Kato-Murayama, M, Ishizuku-Katsura, Y, Tomabechi, Y, Terada, T, Handa, N, Shirouzu, M, Akiyama, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-01-25
Release date:2011-11-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68
Structure, 19, 2011
3NMX
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Crystal structure of APC complexed with Asef
Descriptor: APC variant protein, Rho guanine nucleotide exchange factor 4
Authors:Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G.
Deposit date:2010-06-22
Release date:2011-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the recognition of Asef by adenomatous polyposis coli.
Cell Res., 22, 2012
8GSJ
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BU of 8gsj by Molmil
APC-Asef tripeptide inhibitor
Descriptor: (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ...
Authors:Zhang, J, Wang, X.F, Song, K.
Deposit date:2022-09-06
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:APC-Asef tripeptide inhibitor
To Be Published
5H2X
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BU of 5h2x by Molmil
Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172)
Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1
Authors:Hirano, H, Matsuura, Y.
Deposit date:2016-10-18
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p
J. Mol. Biol., 429, 2017
8G8R
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BU of 8g8r by Molmil
RelB NLS in complex with Importin alpha 2
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Transcription factor RelB
Authors:Tsimbslyuk, S, Stewart, M, Forwood, J.K.
Deposit date:2023-02-19
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:monopartite p52 NLS in complex with Importin alpha 2
To Be Published
8G8S
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BU of 8g8s by Molmil
bipartite p52 NLS in complex with Importin alpha 2
Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p100 subunit isoform X1
Authors:Tsimbslyuk, S, Stewart, M, Forwood, J.K.
Deposit date:2023-02-19
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:p52 bipartite NLS in complex with Importin alpha 2
To Be Published
8G8Q
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BU of 8g8q by Molmil
RelB NLS in complex with Importin alpha 2
Descriptor: Importin subunit alpha-1, bacterial peptide, monopartite p52 NLS
Authors:Tsimbslyuk, S, Stewart, M, Forwood, J.K.
Deposit date:2023-02-19
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:p52 monopartite NLS in complex with Importin alpha 2
To Be Published
8GCN
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BU of 8gcn by Molmil
CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER
Descriptor: Importin subunit alpha-1, Importin subunit beta-1
Authors:Ko, Y, Cingolani, G.
Deposit date:2023-03-02
Release date:2024-03-06
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core.
Sci Adv, 10, 2024
5H43
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Structural and mechanistical studies of the nuclear import by Importin-alpha
Descriptor: Histone acetyltransferase KAT8, Importin subunit alpha-1
Authors:Wang, R, Li, Y.
Deposit date:2016-10-28
Release date:2017-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1
Traffic, 19, 2018
5H2W
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BU of 5h2w by Molmil
Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)
Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1
Authors:Hirano, H, Matsuura, Y.
Deposit date:2016-10-18
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p
J. Mol. Biol., 429, 2017
8HKW
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BU of 8hkw by Molmil
Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal
Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1
Authors:Matsuura, Y.
Deposit date:2022-11-28
Release date:2022-12-21
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal.
Data Brief, 47, 2023
5GXW
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BU of 5gxw by Molmil
Importin and NuMA complex
Descriptor: Importin subunit alpha-1, Peptide from Nuclear mitotic apparatus protein 1
Authors:Chang, C.-C, Huang, T.-L, Hsia, K.-C.
Deposit date:2016-09-20
Release date:2017-10-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Regulation of mitotic spindle assembly factor NuMA by Importin-beta
J. Cell Biol., 216, 2017
8HE3
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BU of 8he3 by Molmil
Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751)
Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1, SULFATE ION
Authors:Matsuura, Y.
Deposit date:2022-11-07
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha.
Biochem.Biophys.Res.Commun., 652, 2023
8HE0
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BU of 8he0 by Molmil
Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type)
Descriptor: Hypoxia-inducible factor 1-alpha, Importin subunit alpha-1
Authors:Matsuura, Y.
Deposit date:2022-11-07
Release date:2023-02-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of importin-alpha bound to the wild-type and an internal deletion mutant of the bipartite nuclear localization signal of HIF-1 alpha.
Biochem.Biophys.Res.Commun., 652, 2023
5HHG
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BU of 5hhg by Molmil
Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex
Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5
Authors:Smith, K.M, Forwood, J.K.
Deposit date:2016-01-11
Release date:2016-05-18
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
PLoS Pathog., 12, 2016
8Y0P
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BU of 8y0p by Molmil
Beta-Catenin in complex with peptide 301
Descriptor: B-cell CLL/lymphoma 9 protein, Catenin beta-1, PROLINE
Authors:Tim, F.
Deposit date:2024-01-22
Release date:2024-04-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Beta-Catenin in complex with peptide 301
To Be Published
5HUY
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BU of 5huy by Molmil
Structure of HCMV Small Terminase NLS bound to importin alpha
Descriptor: HCMV small terminase, Importin subunit alpha-1
Authors:Sankhala, R.S, Lokareddy, R.K, Cingolani, G.
Deposit date:2016-01-28
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.
J.Biol.Chem., 291, 2016
1IAL
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BU of 1ial by Molmil
IMPORTIN ALPHA, MOUSE
Descriptor: IMPORTIN ALPHA
Authors:Kobe, B.
Deposit date:1999-01-12
Release date:1999-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
Nat.Struct.Biol., 6, 1999
5HUW
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BU of 5huw by Molmil
Structure of HSV-1 Large Terminase NLS bound to importin alpha
Descriptor: HSV1 large terminase NLS, Importin subunit alpha-1
Authors:Sankhala, R.S, Lokareddy, R.K, Cingolani, G.
Deposit date:2016-01-27
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.
J.Biol.Chem., 291, 2016
1I7X
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BU of 1i7x by Molmil
BETA-CATENIN/E-CADHERIN COMPLEX
Descriptor: BETA-CATENIN, EPITHELIAL-CADHERIN
Authors:Huber, A.H, Weis, W.I.
Deposit date:2001-03-10
Release date:2001-05-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
Cell(Cambridge,Mass.), 105, 2001
8VPU
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BU of 8vpu by Molmil
Crystal structure of mouse Importin alpha in complex with dengue virus 3 NS5 central NLS peptide
Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 central NLS peptide
Authors:Roman, N, Swarbrick, C.M.D, Forwood, J.K.
Deposit date:2024-01-17
Release date:2024-08-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization.
Acs Infect Dis., 10, 2024

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