1I7X
BETA-CATENIN/E-CADHERIN COMPLEX
Summary for 1I7X
| Entry DOI | 10.2210/pdb1i7x/pdb |
| Related | 1G3J 1I7W 2BCT 3BCT |
| Descriptor | BETA-CATENIN, EPITHELIAL-CADHERIN (3 entities in total) |
| Functional Keywords | e-cadherin, cell adhesion, beta-catenin, protein-protein complex, extended interface, armadillo repeat |
| Biological source | Mus musculus (house mouse) More |
| Cellular location | Cytoplasm: Q02248 Cell junction: P09803 |
| Total number of polymer chains | 4 |
| Total formula weight | 151696.28 |
| Authors | Huber, A.H.,Weis, W.I. (deposition date: 2001-03-10, release date: 2001-05-16, Last modification date: 2023-08-09) |
| Primary citation | Huber, A.H.,Weis, W.I. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell(Cambridge,Mass.), 105:391-402, 2001 Cited by PubMed Abstract: As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly. PubMed: 11348595DOI: 10.1016/S0092-8674(01)00330-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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