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8GGV
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BU of 8ggv by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #14 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGU
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BU of 8ggu by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGX
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BU of 8ggx by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #16 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGY
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BU of 8ggy by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #17 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGW
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BU of 8ggw by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGZ
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BU of 8ggz by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #18 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GH0
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BU of 8gh0 by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #19 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GH1
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BU of 8gh1 by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #20 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8IWM
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BU of 8iwm by Molmil
Cryo-EM structure of the PEA-bound mTAAR9 complex
Descriptor: 2-PHENYLETHYLAMINE, Trace amine-associated receptor 9
Authors:Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
Deposit date:2023-03-30
Release date:2023-05-31
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
8IWE
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BU of 8iwe by Molmil
Cryo-EM structure of the SPE-mTAAR9 complex
Descriptor: SPERMIDINE, Trace amine-associated receptor 9
Authors:Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
Deposit date:2023-03-29
Release date:2023-05-31
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
7O7F
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BU of 7o7f by Molmil
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Descriptor: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ...
Authors:Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S.
Deposit date:2021-04-13
Release date:2021-06-30
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.
Sci Adv, 7, 2021
8CIC
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BU of 8cic by Molmil
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with clinical candidate Etrumadenant
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ...
Authors:Cheng, R.K.Y, Markovic-Mueller, S, Hennig, M.
Deposit date:2023-02-09
Release date:2023-05-31
Last modified:2023-06-14
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.
Commun Chem, 6, 2023
1U19
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BU of 1u19 by Molmil
Crystal Structure of Bovine Rhodopsin at 2.2 Angstroms Resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Okada, T, Sugihara, M, Bondar, A.N, Elstner, M, Entel, P, Buss, V.
Deposit date:2004-07-15
Release date:2004-10-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
J.Mol.Biol., 342, 2004
9IJE
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BU of 9ije by Molmil
Epinephrine-activated human beta3 adrenergic receptor
Descriptor: Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJD
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BU of 9ijd by Molmil
Carazolol-activated human beta3 adrenergic receptor
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
7ARO
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BU of 7aro by Molmil
Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor
Descriptor: 2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ...
Authors:Verdon, G, Amelia, T, van Veldhoven, J, Falsini, M, Liu, R, Heitman, L, van Westen, G, Segala, E, Cheng, R, Cooke, R, van der Es, D, Ijzerman, A.
Deposit date:2020-10-25
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.119 Å)
Cite:Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor.
J.Med.Chem., 64, 2021
7AUE
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BU of 7aue by Molmil
Melanocortin receptor 4 (MC4R) Gs protein complex
Descriptor: AMINOSERINE, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Degtjarik, O, Israeli, H, Prabahar, V, Shalev-Benami, M.
Deposit date:2020-11-02
Release date:2021-04-28
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Science, 372, 2021
1F88
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BU of 1f88 by Molmil
CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, RETINAL, ...
Authors:Okada, T, Palczewski, K, Stenkamp, R.E, Miyano, M.
Deposit date:2000-06-29
Release date:2000-08-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of rhodopsin: A G protein-coupled receptor.
Science, 289, 2000
2PED
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BU of 2ped by Molmil
Crystallographic model of 9-cis-rhodopsin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Nakamichi, H, Okada, T.
Deposit date:2007-04-02
Release date:2007-10-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Photoisomerization mechanism of rhodopsin and 9-cis-rhodopsin revealed by x-ray crystallography
Biophys.J., 92, 2007
1GZM
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BU of 1gzm by Molmil
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, LAURYL DIMETHYLAMINE-N-OXIDE, ...
Authors:Li, J.
Deposit date:2002-05-24
Release date:2003-11-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of Bovine Rhodopsin in a Trigonal Crystal Form
J.Mol.Biol., 343, 2004
4LDO
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BU of 4ldo by Molmil
Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ...
Authors:Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
Deposit date:2013-06-24
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
4LDE
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BU of 4lde by Molmil
Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ...
Authors:Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
Deposit date:2013-06-24
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
4LDL
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BU of 4ldl by Molmil
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ...
Authors:Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
Deposit date:2013-06-24
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
6VMS
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BU of 6vms by Molmil
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Descriptor: Endolysin,D(2) dopamine receptor,D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yin, J, Chen, K.M, Clark, M.J, Hijazi, M, Kumari, P, Bai, X, Sunahara, R.K, Barth, P, Rosenbaum, D.M.
Deposit date:2020-01-28
Release date:2020-06-17
Last modified:2020-08-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
Nature, 584, 2020
6W25
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BU of 6w25 by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119
Descriptor: CALCIUM ION, Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, OLEIC ACID, ...
Authors:Yu, J, Gimenez, L.E, Hernandez, C.C, Wu, Y, Wein, A.H, Han, G.W, McClary, K, Mittal, S.R, Burdsall, K, Stauch, B, Wu, L, Stevens, S.N, Peisley, A, Williams, S.Y, Chen, V, Millhauser, G.L, Zhao, S, Cone, R.D, Stevens, R.C.
Deposit date:2020-03-04
Release date:2020-04-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
Science, 368, 2020

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數據於2024-09-18公開中

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