7ARO

Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor

Summary for 7ARO

Entry DOI	10.2210/pdb7aro/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile, OLEIC ACID, ... (6 entities in total)
Functional Keywords	g protein-coupled receptor, gpcr, receptor, partial agonist, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	49868.62
Authors	Verdon, G.,Amelia, T.,van Veldhoven, J.,Falsini, M.,Liu, R.,Heitman, L.,van Westen, G.,Segala, E.,Cheng, R.,Cooke, R.,van der Es, D.,Ijzerman, A. (deposition date: 2020-10-25, release date: 2021-04-07, Last modification date: 2024-01-31)
Primary citation	Amelia, T.,van Veldhoven, J.P.D.,Falsini, M.,Liu, R.,Heitman, L.H.,van Westen, G.J.P.,Segala, E.,Verdon, G.,Cheng, R.K.Y.,Cooke, R.M.,van der Es, D.,IJzerman, A.P. Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor. J.Med.Chem., 64:3827-3842, 2021 Cited by PubMed: 33764785 DOI: 10.1021/acs.jmedchem.0c01856 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.119 Å)

Structure validation