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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ARO

Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2apolymer43347996.71UniProt (P29274)
UniProt (P0ABE7)
Pfam (PF00001)		Homo sapiens (Human)Cytochrome b-562
2B
(A)		2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrilenon-polymer332.41Chemie (RVZ)
3C, D, E, F
(A)		OLEIC ACIDnon-polymer282.54Chemie (OLA)
PubChem (965)
PubChem (445639)
PubChem (637517)
4G
(A)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
5H
(A)		SODIUM IONnon-polymer23.01Chemie (NA)
PubChem (923)
6I
(A)		waterwater18.01Chemie (HOH)
Sequence modifications
A: 2 - 208 (UniProt: P29274)
PDBExternal DatabaseDetails
Asp -8-expression tag
Tyr -7-expression tag
Lys -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Pro 1-expression tag
Leu 54Ala 54conflict
Ala 88Thr 88conflict
Ala 107Arg 107conflict
Ala 122Lys 122conflict
Ala 154Asn 154conflict
Ala 202Leu 202conflict
A: 1001 - 1106 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Trp 1007Met 29conflict
Ile 1102His 124conflict
Leu 1106Arg 128conflict
A: 219 - 317 (UniProt: P29274)
PDBExternal DatabaseDetails
Ala 235Leu 235conflict
Ala 239Val 239conflict
Ala 277Ser 277conflict
Ala 318-expression tag
His 319-expression tag
His 320-expression tag
His 321-expression tag
His 322-expression tag
His 323-expression tag
His 324-expression tag
His 325-expression tag
His 326-expression tag
His 327-expression tag
His 328-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight47996.7
Non-Polymers*Number of molecules7
Total formula weight1871.9
All*Total formula weight49868.6
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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