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7QXS
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BU of 7qxs by Molmil
Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)
Descriptor: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
Authors:Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
Deposit date:2022-01-27
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
7QXB
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BU of 7qxb by Molmil
Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)
Descriptor: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
Authors:Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
Deposit date:2022-01-26
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
8WUT
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BU of 8wut by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (initiation)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8WUS
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BU of 8wus by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (termination)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (40-MER), DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8WUV
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BU of 8wuv by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 16-nt)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (50-MER), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2023-10-21
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
8YGJ
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BU of 8ygj by Molmil
SpCas9-MMLV RT-pegRNA-target DNA complex (elongation 28-nt)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*TP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*TP*AP*CP*TP*AP*G)-3'), DNA (51-MER), ...
Authors:Shuto, Y, Nakagawa, R, Hoki, M, Omura, S.N, Hirano, H, Itoh, Y, Nureki, O.
Deposit date:2024-02-26
Release date:2024-06-05
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for pegRNA-guided reverse transcription by a prime editor.
Nature, 631, 2024
5CQG
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BU of 5cqg by Molmil
Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532
Descriptor: 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid, Telomerase reverse transcriptase
Authors:Bryan, C, Rice, C, Hoffman, H, Harkisheimer, M, Sweeney, M, Skordalakes, E.
Deposit date:2015-07-21
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.
Structure, 23, 2015
4OL8
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BU of 4ol8 by Molmil
Ty3 reverse transcriptase bound to DNA/RNA
Descriptor: 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ...
Authors:Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M.
Deposit date:2014-01-23
Release date:2014-03-05
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nat.Struct.Mol.Biol., 21, 2014
6USO
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BU of 6uso by Molmil
Telomerase Reverse Transcriptase prenucleotide binary complex, TERT:DNA
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6USP
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BU of 6usp by Molmil
Telomerase Reverse Transcriptase product complex, TERT:DNA
Descriptor: DNA (5'-D(P*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.56 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6ME0
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BU of 6me0 by Molmil
Structure of a group II intron retroelement prior to DNA integration
Descriptor: MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ...
Authors:Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N.
Deposit date:2018-09-05
Release date:2019-08-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Cell, 178, 2019
6USQ
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BU of 6usq by Molmil
Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D, Khoang, T.H.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6USR
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BU of 6usr by Molmil
Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp
Descriptor: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ...
Authors:Schaich, M.A, Freudenthal, B.D.
Deposit date:2019-10-28
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
6MEC
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BU of 6mec by Molmil
Structure of a group II intron retroelement after DNA integration
Descriptor: MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ...
Authors:Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N.
Deposit date:2018-09-06
Release date:2019-08-14
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Cell, 178, 2019
7V99
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BU of 7v99 by Molmil
catalytic core of human telomerase holoenzyme
Descriptor: Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ...
Authors:Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M.
Deposit date:2021-08-24
Release date:2022-03-30
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
5G2X
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BU of 5g2x by Molmil
Structure a of Group II Intron Complexed with its Reverse Transcriptase
Descriptor: 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3', GROUP II INTRON, GROUP II INTRON-ENCODED PROTEIN LTRA
Authors:Qu, G, Kaushal, P.S, Wang, J, Shigematsu, H, Piazza, C.L, Agrawal, R.K, Belfort, M, Wang, H.W.
Deposit date:2016-04-16
Release date:2016-05-11
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of a Group II Intron in Complex with its Reverse Transcriptase.
Nat.Struct.Mol.Biol., 23, 2016
6AR3
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BU of 6ar3 by Molmil
Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Se-Met))
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ...
Authors:Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M.
Deposit date:2017-08-21
Release date:2017-11-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.
Mol. Cell, 68, 2017
6AR1
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BU of 6ar1 by Molmil
Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (RT/Duplex (Nat))
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA, GsI-IIC RT, ...
Authors:Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M.
Deposit date:2017-08-21
Release date:2017-11-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.
Mol. Cell, 68, 2017
3KYL
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BU of 3kyl by Molmil
Structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA
Descriptor: DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*TP*TP*CP*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*G)-3'), MAGNESIUM ION, Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2009-12-06
Release date:2010-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA.
Nat.Struct.Mol.Biol., 17, 2010
4KSE
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BU of 4kse by Molmil
Crystal structure of a HIV p51 (219-230) deletion mutant
Descriptor: 1,2-ETHANEDIOL, HIV p51 subunit
Authors:Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E.
Deposit date:2013-05-17
Release date:2014-08-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.677 Å)
Cite:Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation.
Nucleic Acids Res., 42, 2014
3DU6
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BU of 3du6 by Molmil
Structure of the catalytic subunit of telomerase, TERT
Descriptor: Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
3DU5
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BU of 3du5 by Molmil
Structure of the catalytic subunit of telomerase, TERT
Descriptor: Telomerase reverse transcriptase
Authors:Skordalakes, E.
Deposit date:2008-07-16
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the Tribolium castaneum telomerase catalytic subunit TERT.
Nature, 455, 2008
8FLI
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BU of 8fli by Molmil
Cryo-EM structure of a group II intron immediately before branching
Descriptor: Group II Intron, MAGNESIUM ION, Maturase reverse transcriptase
Authors:Haack, D.B, Rudolfs, B.G, Zhang, C, Lyumkis, D, Toor, N.
Deposit date:2022-12-21
Release date:2023-12-13
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of branching during RNA splicing.
Nat.Struct.Mol.Biol., 31, 2024
7TRD
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BU of 7trd by Molmil
Human telomerase catalytic core structure at 3.3 Angstrom
Descriptor: Telomerase RNA, partial sequence, Telomerase reverse transcriptase, ...
Authors:Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J.
Deposit date:2022-01-28
Release date:2022-04-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
7TRE
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BU of 7tre by Molmil
Human telomerase catalytic core with shelterin protein TPP1
Descriptor: Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ...
Authors:Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J.
Deposit date:2022-01-28
Release date:2022-04-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022

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PDB entries from 2024-09-18

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