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3KLS
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BU of 3kls by Molmil
Structure of complement C5 in complex with SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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BU of 3km9 by Molmil
Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3L3O
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BU of 3l3o by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3c
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V, Garcia, B.G.
Deposit date:2009-12-17
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
6YO6
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BU of 6yo6 by Molmil
Structure of iC3b1
Descriptor: hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain
Authors:Jensen, R.K, Andersen, G.R.
Deposit date:2020-04-14
Release date:2021-02-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (6 Å)
Cite:Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b.
J Immunol., 206, 2021
3L5N
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BU of 3l5n by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor, ...
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
6YSQ
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BU of 6ysq by Molmil
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Descriptor: Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ...
Authors:Zarantonello, A, Laursen, N.S, Andersen, G.R.
Deposit date:2020-04-23
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
5HCC
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BU of 5hcc by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3.
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jore, M.M, Johnson, S, Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
3PVM
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BU of 3pvm by Molmil
Structure of Complement C5 in Complex with CVF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5
Authors:Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
6RU5
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BU of 6ru5 by Molmil
human complement C3 in complex with the hC3Nb1 nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jensen, R.K, Andersen, G.R.
Deposit date:2019-05-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019
6RUR
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BU of 6rur by Molmil
Structure of the SCIN stabilized C3bBb convertase bound to properdin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, ...
Authors:Pedersen, D.V, Gadeberg, T.A.F, Andersen, G.R.
Deposit date:2019-05-29
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (6 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019
3OHX
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BU of 3ohx by Molmil
Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V, Garcia, B.L.
Deposit date:2010-08-18
Release date:2010-09-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
4RTD
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BU of 4rtd by Molmil
Escherichia coli alpha-2-macroglobulin activated by porcine elastase
Descriptor: Uncharacterized lipoprotein YfhM
Authors:Fyfe, C.D, Grinter, R, Roszak, A.W, Josts, I, Cogdell, R.J, Walker, D.
Deposit date:2014-11-14
Release date:2015-07-15
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structure of protease-cleaved Escherichia coli alpha-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.
Acta Crystallogr.,Sect.D, 71, 2015
5HCD
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BU of 5hcd by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ...
Authors:Jore, M.M, Johnson, S, Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
7AD6
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BU of 7ad6 by Molmil
Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide.
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ...
Authors:Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
Deposit date:2020-09-14
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
7AD7
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BU of 7ad7 by Molmil
Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
Deposit date:2020-09-14
Release date:2021-03-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
5HCE
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BU of 5hce by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ...
Authors:Jore, M.M, Johnson, S, Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
4U48
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BU of 4u48 by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin
Descriptor: Putative inner membrane lipoprotein
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
4U4J
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BU of 4u4j by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin mutant Y1175G
Descriptor: Putative inner membrane lipoprotein
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-23
Release date:2014-09-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
6RQJ
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BU of 6rqj by Molmil
Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ...
Authors:Reichhardt, M.P, Johnson, S, Lea, S.M.
Deposit date:2019-05-15
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:An inhibitor of complement C5 provides structural insights into activation.
Proc.Natl.Acad.Sci.USA, 117, 2020
4U59
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BU of 4u59 by Molmil
Crystal structure of Salmonella alpha-2-macroglobulin reacted with methylamine
Descriptor: alpha-2-macroglobulin
Authors:Wong, S.G, Dessen, A.
Deposit date:2014-07-24
Release date:2014-09-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Nat Commun, 5, 2014
3PRX
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BU of 3prx by Molmil
Structure of Complement C5 in Complex with CVF and SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ...
Authors:Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
6RUV
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BU of 6ruv by Molmil
Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory nanobody hFPNb1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, ...
Authors:Pedersen, D.V, Andersen, G.R.
Deposit date:2019-05-29
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (6.15 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019
5I5K
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BU of 5i5k by Molmil
Structure of complement C5 in complex with eculizumab
Descriptor: Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain), ...
Authors:Schatz-Jakobsen, J.A, Andersen, G.R.
Deposit date:2016-02-15
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
J Immunol., 197, 2016
5FOB
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BU of 5fob by Molmil
Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COMPLEMENT C3 BETA CHAIN, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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BU of 5foa by Molmil
Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)
Descriptor: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F, Wu, J, Xue, X, Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016

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