6RUV

Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory nanobody hFPNb1

Summary for 6RUV

Entry DOI	10.2210/pdb6ruv/pdb
Descriptor	Nanobody hFPNb1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (12 entities in total)
Functional Keywords	innate immunity, complement, proteolytic enzyme, regulator, nanobody, immune system
Biological source	Lama glama More
Total number of polymer chains	14
Total formula weight	610525.62
Authors	Pedersen, D.V.,Andersen, G.R. (deposition date: 2019-05-29, release date: 2019-08-21, Last modification date: 2024-01-24)
Primary citation	Pedersen, D.V.,Gadeberg, T.A.F.,Thomas, C.,Wang, Y.,Joram, N.,Jensen, R.K.,Mazarakis, S.M.M.,Revel, M.,El Sissy, C.,Petersen, S.V.,Lindorff-Larsen, K.,Thiel, S.,Laursen, N.S.,Fremeaux-Bacchi, V.,Andersen, G.R. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol, 10:2007-2007, 2019 Cited by PubMed: 31507604 DOI: 10.3389/fimmu.2019.02007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (6.15 Å)

Structure validation