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7DVQ
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BU of 7dvq by Molmil
Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ...
Authors:Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y.
Deposit date:2021-01-14
Release date:2021-03-31
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structure of the activated human minor spliceosome.
Science, 371, 2021
6ID0
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BU of 6id0 by Molmil
Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ...
Authors:Zhang, X, Zhan, X, Yan, C, Shi, Y.
Deposit date:2018-09-07
Release date:2019-03-13
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
8RO0
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BU of 8ro0 by Molmil
Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
Descriptor: Cell division cycle 5-like protein, Coiled-coil domain-containing protein 12, GCF C-terminal domain-containing protein, ...
Authors:Vorlaender, M.K, Rothe, P, Plaschka, C.
Deposit date:2024-01-11
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
5XJT
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BU of 5xjt by Molmil
Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1(1-82)/D2.R61A/F/E/G from Human
Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ...
Authors:Yi, H, Zhang, R.
Deposit date:2017-05-04
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structures of 7S mutant complexes
To Be Published
6QW6
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BU of 6qw6 by Molmil
Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Charenton, C, Wilkinson, M.E, Nagai, K.
Deposit date:2019-03-05
Release date:2019-04-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
4M75
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BU of 4m75 by Molmil
Crystal structure of Lsm1-7 complex
Descriptor: CHLORIDE ION, U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, ...
Authors:Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y.
Deposit date:2013-08-12
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
6YGC
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BU of 6ygc by Molmil
Crystal structure of the NatC complex bound to Arl3 peptide and CoA
Descriptor: ADP-ribosylation factor-like protein 3, CHLORIDE ION, COENZYME A, ...
Authors:Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O.
Deposit date:2020-03-27
Release date:2020-10-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020
6ICZ
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BU of 6icz by Molmil
Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Zhang, X, Zhan, X, Yan, C, Shi, Y.
Deposit date:2018-09-07
Release date:2019-03-13
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
8RO1
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BU of 8ro1 by Molmil
Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS'')
Descriptor: CWF19-like protein 1 homolog, CWF19-like protein 2 homolog, Cell division cycle 5-like protein, ...
Authors:Vorlaender, M.K, Rothe, P, Plaschka, C.
Deposit date:2024-01-11
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism for the initiation of spliceosome disassembly.
Nature, 632, 2024
8I0T
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BU of 8i0t by Molmil
The cryo-EM structure of human Bact-III complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2023-01-11
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
8I0V
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BU of 8i0v by Molmil
The cryo-EM structure of human post-Bact complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2023-01-11
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
8I0R
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BU of 8i0r by Molmil
The cryo-EM structure of human Bact-I complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2023-01-11
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for the activation of human spliceosome.
Nat Commun, 15, 2024
7VPX
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BU of 7vpx by Molmil
The cryo-EM structure of the human pre-A complex
Descriptor: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-10-18
Release date:2023-05-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
8Q91
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BU of 8q91 by Molmil
Structure of the human 20S U5 snRNP core
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Schneider, S, Galej, W.P.
Deposit date:2023-08-19
Release date:2024-03-27
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
4V98
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BU of 4v98 by Molmil
The 8S snRNP Assembly Intermediate
Descriptor: CG10419, Icln, LD23602p, ...
Authors:Grimm, C, Pelz, J.P, Schindelin, H, Diederichs, K, Kuper, J, Kisker, C.
Deposit date:2012-05-15
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Assembly Chaperone- Mediated snRNP Formation.
Mol.Cell, 49, 2013
5VSU
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BU of 5vsu by Molmil
Structure of yeast U6 snRNP with 2'-phosphate terminated U6 RNA
Descriptor: Saccharomyces cerevisiae strain T8 chromosome XII sequence, U4/U6 snRNA-associated-splicing factor PRP24, U6 snRNA-associated Sm-like protein LSm2, ...
Authors:Montemayor, E.J.
Deposit date:2017-05-12
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA.
Nat Commun, 9, 2018
7QTT
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BU of 7qtt by Molmil
Structural organization of a late activated human spliceosome (Baqr, core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Pena, V.
Deposit date:2022-01-15
Release date:2023-05-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
4M77
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BU of 4m77 by Molmil
Crystal structure of Lsm2-8 complex, space group I212121
Descriptor: U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, ...
Authors:Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y.
Deposit date:2013-08-12
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.111 Å)
Cite:Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
Nature, 506, 2014
5XJR
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BU of 5xjr by Molmil
Crystal Structure of the Gemin2-binding domain of SMN, Gemin2dN39 in Complex with SmD1(1-82)/D2/F/E/G from Human
Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ...
Authors:Yi, H, Zhang, R.
Deposit date:2017-05-04
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.
Nucleic Acids Res., 2019
4N0A
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BU of 4n0a by Molmil
Crystal structure of Lsm2-3-Pat1C complex from Saccharomyces cerevisiae
Descriptor: DNA topoisomerase 2-associated protein PAT1, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3
Authors:Wu, D.H.
Deposit date:2013-10-01
Release date:2013-12-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation
Cell Res., 24, 2014
7L1K
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BU of 7l1k by Molmil
Cryo-EM structure of S. Pombe NatC complex with a Bisubstrate inhibitor and inositol hexaphosphate
Descriptor: CARBOXYMETHYL COENZYME *A, INOSITOL HEXAKISPHOSPHATE, MLGP peptide, ...
Authors:Deng, S, Marmorstein, R.
Deposit date:2020-12-14
Release date:2021-05-12
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Molecular mechanism of N-terminal acetylation by the ternary NatC complex.
Structure, 29, 2021
8RC0
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BU of 8rc0 by Molmil
Structure of the human 20S U5 snRNP
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Schneider, S, Galej, W.P.
Deposit date:2023-12-05
Release date:2024-03-27
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
6J6G
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BU of 6j6g by Molmil
Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom
Descriptor: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y.
Deposit date:2019-01-15
Release date:2019-04-24
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
8Q7Q
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BU of 8q7q by Molmil
Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Riabov Bassat, D, Plaschka, C, Vorlaender, M.K.
Deposit date:2023-08-16
Release date:2024-04-17
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
6N7R
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BU of 6n7r by Molmil
Saccharomyces cerevisiae spliceosomal E complex (ACT1)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ...
Authors:Liu, S, Li, X, Zhou, Z.H, Zhao, R.
Deposit date:2018-11-28
Release date:2019-09-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019

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