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4OH0
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BU of 4oh0 by Molmil
Crystal structure of OXA-58 carbapenemase
Descriptor: Beta-lactamase OXA-58, CHLORIDE ION
Authors:Smith, C.A, Antunes, N.T, Toth, M, Vakulenko, S.B.
Deposit date:2014-01-16
Release date:2014-02-26
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of Carbapenemase OXA-58 from Acinetobacter baumannii.
Antimicrob.Agents Chemother., 58, 2014
8RTZ
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BU of 8rtz by Molmil
The structure of E. coli penicillin binding protein 3 (PBP3) in complex with a bicyclic peptide inhibitor
Descriptor: 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, Bicyclic peptide inhibitor, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Rowland, C.E, Dods, R, Lewis, N, Stanway, S.J, Bellini, D, Beswick, P.
Deposit date:2024-01-29
Release date:2024-04-03
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle) Antimicrobial Inhibitor of Escherichia coli PBP3
To Be Published
8SQ8
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X-ray crystal structure of Acinetobacter baumanii beta-lactamase variant OXA-109 in complex with doripenem
Descriptor: (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, Beta-lactamase OXA-109
Authors:Powers, R.A, Leonard, D.A, June, C.M, Szarecka, A, Wawrzak, Z.
Deposit date:2023-05-04
Release date:2024-05-22
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural and Dynamic Features of Acinetobacter baumannii OXA-66 beta-Lactamase Explain Its Stability and Evolution of Novel Variants.
J.Mol.Biol., 436, 2024
8SQ7
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BU of 8sq7 by Molmil
X-ray crystal structure of Acinetobacter baumanii beta-lactamase variant OXA-82 K83D in complex with doripenem
Descriptor: (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase OXA-82, CITRATE ANION, ...
Authors:Powers, R.A, Leonard, D.A, June, C.M, Szarecka, A, Wawrzak, Z.
Deposit date:2023-05-04
Release date:2024-05-22
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural and Dynamic Features of Acinetobacter baumannii OXA-66 beta-Lactamase Explain Its Stability and Evolution of Novel Variants.
J.Mol.Biol., 436, 2024
8SQF
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BU of 8sqf by Molmil
OXA-48 bound to inhibitor CDD-2725
Descriptor: (1M)-3'-(benzyloxy)-5-hydroxy[1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, Beta-lactamase
Authors:Park, S, Judge, A, Fan, J, Sankaran, B, Prasad, B.V.V, Palzkill, T.
Deposit date:2023-05-04
Release date:2024-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.
J.Med.Chem., 67, 2024
8SQG
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BU of 8sqg by Molmil
OXA-48 bound to inhibitor CDD-2801
Descriptor: (1M)-3'-(benzyloxy)-5-[2-(methylamino)-2-oxoethoxy][1,1'-biphenyl]-3,4'-dicarboxylic acid, BICARBONATE ION, Beta-lactamase
Authors:Park, S, Judge, A, Fan, J, Sankaran, B, Palzkill, T.
Deposit date:2023-05-04
Release date:2024-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Exploiting the Carboxylate-Binding Pocket of beta-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.
J.Med.Chem., 67, 2024
3FV7
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BU of 3fv7 by Molmil
OXA-24 beta-lactamase complex with SA4-44 inhibitor
Descriptor: (2S)-2-[[2-methanoyl-7-(methoxycarbonylamino)indolizin-3-yl]amino]-3-methyl-3-sulfino-butanoic acid, Beta-lactamase OXA-24
Authors:Bou, G, Santillana, E, Sheri, A, Beceiro, A, Sampson, J.M, Kalp, M, Bethel, C.R, Distler, A.M, Drawz, S.M, Pagadala, S.R, Van den Akker, F, Bonomo, R.A, Romero, A, Buynak, J.D.
Deposit date:2009-01-15
Release date:2010-02-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
J.Am.Chem.Soc., 132, 2010
3FYZ
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BU of 3fyz by Molmil
OXA-24 beta-lactamase complex with SA4-17 inhibitor
Descriptor: (2S,3R)-2-[(7-aminocarbonyl-2-methanoyl-indolizin-3-yl)amino]-4-aminocarbonyloxy-3-methyl-3-sulfino-butanoic acid, Beta-lactamase OXA-24, TETRAETHYLENE GLYCOL
Authors:Romero, A, Santillana, E.
Deposit date:2009-01-23
Release date:2010-02-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
J.Am.Chem.Soc., 132, 2010
3FZC
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BU of 3fzc by Molmil
OXA-24 beta-lactamase complex with SA3-53 inhibitor
Descriptor: (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid, Beta-lactamase OXA-24, TETRAETHYLENE GLYCOL
Authors:Romero, A, Santillana, E.
Deposit date:2009-01-24
Release date:2010-02-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
J.Am.Chem.Soc., 132, 2010
1NRF
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BU of 1nrf by Molmil
C-terminal domain of the Bacillus licheniformis BlaR penicillin-receptor
Descriptor: REGULATORY PROTEIN BLAR1
Authors:Kerff, F, Charlier, P, Columbo, M.L, Sauvage, E, Brans, A, Frere, J.M, Joris, B, Fonze, E.
Deposit date:2003-01-24
Release date:2004-01-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis.
Biochemistry, 42, 2003
1M6K
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BU of 1m6k by Molmil
Structure of the OXA-1 class D beta-lactamase
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, beta-lactamase OXA-1
Authors:Sun, T, Nukaga, M, Mayama, K, Braswell, E.H, Knox, J.R.
Deposit date:2002-07-16
Release date:2003-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Comparison of beta-lactamases of classes A and D: 1.5A crystallographic structure of the class D OXA-1 oxacillinase
PROTEIN SCI., 12, 2003
8VBZ
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BU of 8vbz by Molmil
Crystal structure of the transpeptidase domain of a S310A mutant of PBP2 from Neisseria gonorrhoeae strain H041
Descriptor: Probable peptidoglycan D,D-transpeptidase PenA
Authors:Stratton, C, Bala, S, Davies, C.
Deposit date:2023-12-13
Release date:2024-03-20
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
8C0P
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BU of 8c0p by Molmil
Crystal structure of S. aureus BlaR1 sensor domain in complex with a boronate inhibitor
Descriptor: Regulatory protein BlaR1, [1-[[2,4-bis(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]sulfanylmethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron
Authors:Miguel-Ruano, V, Jimenez-Faraco, E, Hermoso, J.A.
Deposit date:2022-12-19
Release date:2024-07-10
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus.
Nat.Chem.Biol., 2024
8C0S
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BU of 8c0s by Molmil
Crystal structure of S. aureus BlaR1 sensor domain in complex with an imidazole inhibitor
Descriptor: 3-[[2,4-bis(trifluoromethyl)phenyl]methyl]-5-(hydroxymethyl)-1~{H}-imidazole-2-thione, Regulatory protein BlaR1
Authors:Miguel-Ruano, V, Hermoso, J.A.
Deposit date:2022-12-19
Release date:2024-07-10
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus.
Nat.Chem.Biol., 2024
8CF3
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BU of 8cf3 by Molmil
Crystal structure of S. aureus BlaR1 sensor domain in complex with cefepime
Descriptor: Cefepime (open), Regulatory protein BlaR1
Authors:Miguel-Ruano, V, Hermoso, J.A.
Deposit date:2023-02-02
Release date:2024-09-04
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus.
Nat.Chem.Biol., 2024
4Z9Q
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BU of 4z9q by Molmil
Crystal structure of OXA-58 with disordered active site
Descriptor: Beta-lactamase OXA-58
Authors:Pratap, S, Gill, P.K, Golemi-Kotra, D, Kumar, P.
Deposit date:2015-04-11
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of OXA-58 with disordered active site
To Be Published
4ZDX
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BU of 4zdx by Molmil
Structure of OXA-51 beta-lactamase
Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, Beta-lactamase, GLYCEROL
Authors:Smith, C.A, Antunes, N.T, Stewart, N.K, Frase, H, Toth, M, Kantardjieff, K.A, Vakulenko, S.B.
Deposit date:2015-04-20
Release date:2015-06-17
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D beta-Lactamases.
Acs Chem.Biol., 10, 2015
8CUL
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BU of 8cul by Molmil
Xray ray crystal structure of OXA-24/40 in complex with CR167
Descriptor: 3-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase
Authors:Fernando, M.C, Wallar, B.J, Powers, R.A.
Deposit date:2022-05-17
Release date:2023-04-05
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii .
Antibiotics, 12, 2023
8CUO
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BU of 8cuo by Molmil
X-ray crystal structure of OXA-24/40 in complex with sulfonamidoboronic acid 6e
Descriptor: 3-({[(1R)-1-boronopropyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, SULFATE ION
Authors:Fernando, M.C, Wallar, B.J, Powers, R.A.
Deposit date:2022-05-17
Release date:2023-04-05
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii .
Antibiotics, 12, 2023
8CUM
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BU of 8cum by Molmil
X-ray crystal structure of OXA-24/40 in complex with sulfonamidoboronic acid 6d
Descriptor: 3-({[(1S)-1-boronopropyl]sulfamoyl}methyl)benzoic acid, Beta-lactamase, SULFATE ION
Authors:Fernando, M.C, Wallar, B.J, Powers, R.A.
Deposit date:2022-05-17
Release date:2023-04-05
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii .
Antibiotics, 12, 2023
4YIN
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BU of 4yin by Molmil
Crystal structure of the extended-spectrum beta-lactamase OXA-145
Descriptor: Beta-lactamase, CITRATE ANION
Authors:Meziane-Cherif, D, Bonnet, R, Haouz, A, Courvalin, P.
Deposit date:2015-03-02
Release date:2016-02-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 beta-lactamase in Pseudomonas aeruginosa.
J. Antimicrob. Chemother., 71, 2016
8VEN
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BU of 8ven by Molmil
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with cefoperazone
Descriptor: (2R,4R)-2-[(1R)-1-{[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methylidene-1,3-thiazinane-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA
Authors:Stratton, C, Bala, S, Davies, C.
Deposit date:2023-12-20
Release date:2024-03-20
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
8VEP
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BU of 8vep by Molmil
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 acylated by piperacillin
Descriptor: DI(HYDROXYETHYL)ETHER, Piperacillin (Open Form), Probable peptidoglycan D,D-transpeptidase PenA
Authors:Stratton, C.M, Bala, S, Davies, C.
Deposit date:2023-12-20
Release date:2024-03-20
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
8VEQ
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BU of 8veq by Molmil
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with azlocillin
Descriptor: (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA
Authors:Stratton, C, Bala, S, Davies, C.
Deposit date:2023-12-20
Release date:2024-03-20
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.
Acs Infect Dis., 10, 2024
6ZRI
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BU of 6zri by Molmil
Crystal structure of OXA-10loop24 in complex with meropenem
Descriptor: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase
Authors:Tassone, G, Di Pisa, F, Benvenuti, M, De Luca, F, Pozzi, C, Mangani, S, Docquier, J.D.
Deposit date:2020-07-13
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48
To Be Published

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PDB entries from 2024-09-18

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