8VEN
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with cefoperazone
This is a non-PDB format compatible entry.
Summary for 8VEN
| Entry DOI | 10.2210/pdb8ven/pdb |
| Descriptor | Probable peptidoglycan D,D-transpeptidase PenA, (2R,4R)-2-[(1R)-1-{[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methylidene-1,3-thiazinane-4-carboxylic acid (3 entities in total) |
| Functional Keywords | penicillin-binding protein, transpeptidase, complex, hydrolase |
| Biological source | Neisseria gonorrhoeae |
| Total number of polymer chains | 1 |
| Total formula weight | 35895.05 |
| Authors | Stratton, C.,Bala, S.,Davies, C. (deposition date: 2023-12-20, release date: 2024-03-20, Last modification date: 2024-04-24) |
| Primary citation | Turner, J.M.,Stratton, C.M.,Bala, S.,Cardenas Alvarez, M.,Nicholas, R.A.,Davies, C. Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041. Acs Infect Dis., 10:1298-1311, 2024 Cited by PubMed: 38446051DOI: 10.1021/acsinfecdis.3c00713 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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