8C0P

Crystal structure of S. aureus BlaR1 sensor domain in complex with a boronate inhibitor

Summary for 8C0P

• Entry DOI: 10.2210/pdb8c0p/pdb
• Descriptor: Regulatory protein BlaR1, [1-[[2,4-bis(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]sulfanylmethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total)
• Functional Keywords: antibiotic resistance, beta-lactam sensor of staphylococcus aureus, mrsa, signaling protein
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 2
• Total formula weight: 60443.21

Authors

Miguel-Ruano, V.,Jimenez-Faraco, E.,Hermoso, J.A. (deposition date: 2022-12-19, release date: 2024-07-10)

• Primary citation: Miguel-Ruano, V.,Jimenez Faraco, E.,Alba-Perez, A.,Hermoso, J.A.; Restoring Susceptibility to b-Lactam Antibiotics in Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)