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4XUA
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BU of 4xua by Molmil
Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue
Descriptor: 1,2-ETHANEDIOL, 4-{1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}benzonitrile, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-01-25
Release date:2015-03-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
4WHU
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BU of 4whu by Molmil
BROMO domain of CREB binding protein
Descriptor: 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, CREB-binding protein
Authors:Liu, S.
Deposit date:2014-09-23
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Direct photocapture of bromodomains using tropolone chemical probes
To Be Published
4WHW
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BU of 4whw by Molmil
Direct photocapture of bromodomains using tropolone chemical probes
Descriptor: 1,2-ETHANEDIOL, 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, Bromodomain-containing protein 4
Authors:Hett, E.C, Piatnitski Chekler, E.L, Basak, A, Bonin, P.D, Denny, R.A, Flick, A.C, Geoghegan, K.F, Liu, S, Pletcher, M.T, Robinson, R.P, Sahasrabudhe, P, Salter, S, Stock, I.A, Jones, L.H.
Deposit date:2014-09-23
Release date:2015-10-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.345 Å)
Cite:Direct photocapture of bromodomains using tropolone chemical probes
To Be Published
4XYA
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BU of 4xya by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand
Descriptor: 1,2-ETHANEDIOL, 6-(5-bromo-1-benzofuran-7-yl)-9H-purin-2-amine, Bromodomain-containing protein 4
Authors:Picaud, S, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2015-02-02
Release date:2015-03-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain.
J.Med.Chem., 58, 2015
4XUB
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BU of 4xub by Molmil
Crystal Structure of the bromodomain of human BAZ2B in complex with BAZ2-ICR chemical probe
Descriptor: 1,2-ETHANEDIOL, 4-{4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-1H-imidazol-5-yl}benzonitrile, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-01-25
Release date:2015-03-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.
J.Med.Chem., 58, 2015
4XY8
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BU of 4xy8 by Molmil
Crystal Structure of the bromodomain of BRD9 in complex with a 2-amine-9H-purine ligand
Descriptor: 6-(5-bromo-2-methoxyphenyl)-9H-purin-2-amine, BROMIDE ION, Bromodomain-containing protein 9
Authors:Picaud, S, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2015-02-02
Release date:2015-03-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain.
J.Med.Chem., 58, 2015
3LJW
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BU of 3ljw by Molmil
Crystal Structure of the Second Bromodomain of Human Polybromo
Descriptor: ACETATE ION, Protein polybromo-1, SODIUM ION
Authors:Charlop-Powers, Z, Zhou, M.M, Zeng, L, Zhang, Q.
Deposit date:2010-01-26
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Cell Res., 20, 2010
4X2I
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BU of 4x2i by Molmil
Discovery of benzotriazolo diazepines as orally-active inhibitors of BET bromodomains: Crystal structure of BRD4 with CPI-13
Descriptor: (4R)-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, Bromodomain-containing protein 4, FORMIC ACID
Authors:Bellon, S.F, Jayaram, H, Poy, F.
Deposit date:2014-11-26
Release date:2015-11-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
Acs Med.Chem.Lett., 7, 2016
3LXJ
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BU of 3lxj by Molmil
Crystal Structure of the Bromodomain of Human AAA domain containing 2B (ATAD2B)
Descriptor: ATPase family AAA domain-containing protein 2B, ISOPROPYL ALCOHOL
Authors:Filippakopoulos, P, Keates, T, Picaud, S, Fedorov, O, Krojer, T, Vollmar, M, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-02-25
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MB4
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BU of 3mb4 by Molmil
Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP
Descriptor: 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, CHLORIDE ION, ...
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MQM
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BU of 3mqm by Molmil
Crystal Structure of the Bromodomain of human ASH1L
Descriptor: Probable histone-lysine N-methyltransferase ASH1L
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Felletar, I, Vollmar, M, Chaikuad, A, Krojer, T, Canning, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-04-28
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MB3
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BU of 3mb3 by Molmil
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP)
Descriptor: 1-methylpyrrolidin-2-one, PH-interacting protein
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MXF
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BU of 3mxf by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1
Descriptor: (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ...
Authors:Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective inhibition of BET bromodomains.
Nature, 468, 2010
6I80
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BU of 6i80 by Molmil
Crystal Structure of the second bromodomain of BRD2 in complex with RT53
Descriptor: 1,2-ETHANEDIOL, 2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone, Bromodomain-containing protein 2
Authors:Picaud, S, Traquete, R, Bernardes, G.J.L, Newman, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2018-11-19
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Crystal Structure of the second bromodomain of BRD2 in complex with RT53
To Be Published
6IN1
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BU of 6in1 by Molmil
Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, ...
Authors:Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
Deposit date:2018-10-24
Release date:2019-10-30
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6I7X
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BU of 6i7x by Molmil
Crystal Structure of the first bromodomain of BRD4 in complex with RT53
Descriptor: 1,2-ETHANEDIOL, 2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone, Bromodomain-containing protein 4
Authors:Picaud, S, Traquete, R, Bernardes, G.J.L, Newman, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2018-11-19
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of the first bromodomain of BRD4 in complex with RT53
To Be Published
6I81
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BU of 6i81 by Molmil
Crystal Structure of the second bromodomain of BRD2 in complex with RT56
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2, ...
Authors:Picaud, S, Traquete, R, Bernardes, G.J.L, Newman, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2018-11-19
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal Structure of the second bromodomain of BRD2 in complex with RT56
To Be Published
6I7Y
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BU of 6i7y by Molmil
Crystal Structure of the first bromodomain of BRD4 in complex with RT56
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, [1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]phenyl]piperidin-4-yl]-trimethyl-azanium
Authors:Picaud, S, Traquete, R, Bernardes, G.J.L, Newman, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC)
Deposit date:2018-11-19
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal Structure of the first bromodomain of BRD4 in complex with RT56
To Be Published
2I7K
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BU of 2i7k by Molmil
Solution Structure of the Bromodomain of Human BRD7 Protein
Descriptor: Bromodomain-containing protein 7
Authors:Sun, H, Liu, J, Zhang, J, Huang, H, Wu, J, Shi, Y.
Deposit date:2006-08-31
Release date:2007-07-10
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
Biochem.Biophys.Res.Commun., 358, 2007
2I8N
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BU of 2i8n by Molmil
Solution structure of the second bromodomain of Brd4
Descriptor: Bromodomain-containing protein 4
Authors:Liu, Y, Wu, J.H, Shi, Y.Y.
Deposit date:2006-09-02
Release date:2007-09-04
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the second bromodomain of Brd4
To be Published
2G4A
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BU of 2g4a by Molmil
Solution structure of a Bromodomain from RING3 protein
Descriptor: Bromodomain-containing protein 2
Authors:Huang, H, Wu, J, Shi, Y.
Deposit date:2006-02-21
Release date:2007-02-27
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of a Bromodomain from RING3
to be published
2H60
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BU of 2h60 by Molmil
Solution Structure of Human Brg1 Bromodomain
Descriptor: Probable global transcription activator SNF2L4
Authors:Shen, W, Xu, C, Zhang, J, Wu, J, Shi, Y.
Deposit date:2006-05-30
Release date:2007-02-13
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails
Biochemistry, 46, 2007
2GRC
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BU of 2grc by Molmil
1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex
Descriptor: Probable global transcription activator SNF2L4
Authors:Singh, M, Popowicz, G.M, Krajewski, M, Holak, T.A.
Deposit date:2006-04-24
Release date:2007-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
5MKX
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BU of 5mkx by Molmil
1.68A STRUCTURE PCAF BROMODOMAIN WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one
Descriptor: 1,4-BUTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one, ...
Authors:Chung, C.-W.
Deposit date:2016-12-05
Release date:2017-12-20
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
J. Med. Chem., 60, 2017
5MME
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BU of 5mme by Molmil
Crystal structure of CREBBP bromodomain complexd with US46C
Descriptor: CREB-binding protein, dimethyl 5-[(5-ethanoyl-2-ethoxy-phenyl)amino]benzene-1,3-dicarboxylate
Authors:Zhu, J, Caflisch, A.
Deposit date:2016-12-09
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018

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