4XUB

Crystal Structure of the bromodomain of human BAZ2B in complex with BAZ2-ICR chemical probe

Summary for 4XUB

• Entry DOI: 10.2210/pdb4xub/pdb
• Related: 4XUA
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, 4-{4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-1H-imidazol-5-yl}benzonitrile, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4, sgc, structural genomics consortium
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9UIF8
• Total number of polymer chains: 1
• Total formula weight: 14163.26

Authors

Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-01-25, release date: 2015-03-11, Last modification date: 2024-01-10)

• Primary citation: Drouin, L.,McGrath, S.,Vidler, L.R.,Chaikuad, A.,Monteiro, O.,Tallant, C.,Philpott, M.,Rogers, C.,Fedorov, O.,Liu, M.,Akhtar, W.,Hayes, A.,Raynaud, F.,Muller, S.,Knapp, S.,Hoelder, S.; Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B.; J.Med.Chem., 58:2553-2559, 2015; PubMed: 25719566; DOI: 10.1021/jm501963e

Experimental method

X-RAY DIFFRACTION (1.98 Å)