4XUA
Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue
Summary for 4XUA
Entry DOI | 10.2210/pdb4xua/pdb |
Descriptor | Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 4-{1-[2-(4-methyl-1H-1,2,3-triazol-1-yl)ethyl]-4-phenyl-1H-imidazol-5-yl}benzonitrile, ... (4 entities in total) |
Functional Keywords | transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q9UIF8 |
Total number of polymer chains | 1 |
Total formula weight | 14221.33 |
Authors | Chaikuad, A.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-01-25, release date: 2015-03-11, Last modification date: 2024-01-10) |
Primary citation | Drouin, L.,McGrath, S.,Vidler, L.R.,Chaikuad, A.,Monteiro, O.,Tallant, C.,Philpott, M.,Rogers, C.,Fedorov, O.,Liu, M.,Akhtar, W.,Hayes, A.,Raynaud, F.,Muller, S.,Knapp, S.,Hoelder, S. Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem., 58:2553-2559, 2015 Cited by PubMed: 25719566DOI: 10.1021/jm501963e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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