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5L19
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Crystal Structure of a human FasL mutant
Descriptor: SULFATE ION, Tumor necrosis factor ligand superfamily member 6, ZINC ION
Authors:Liu, W, Bonanno, J.B, Almo, S.C.
Deposit date:2016-07-28
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
1D2Q
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CRYSTAL STRUCTURE OF HUMAN TRAIL
Descriptor: TNF-RELATED APOPTOSIS INDUCING LIGAND
Authors:Cha, S.-S.
Deposit date:1999-09-27
Release date:2000-02-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.
Immunity, 11, 1999
5M2J
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BU of 5m2j by Molmil
Complex between human TNF alpha and Llama VHH2
Descriptor: Anti-(ED-B) scFV, Tumor necrosis factor
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
5M2M
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Complex between human TNF alpha and Llama VHH3
Descriptor: Llama nanobody VHH3, Tumor necrosis factor
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
4KG8
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Crystal structure of light mutant
Descriptor: Tumor necrosis factor ligand superfamily member 14
Authors:Liu, W, Zhan, C, Kumar, P.R, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
Deposit date:2013-04-28
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
5M2I
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Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1
Descriptor: Tumor necrosis factor, VHH1
Authors:Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H.
Deposit date:2016-10-13
Release date:2017-08-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
7KHX
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Mouse GITR-GITRL complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ...
Authors:Wang, F, Chau, B, West, S.M, Strop, P.
Deposit date:2020-10-22
Release date:2021-03-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.20569849 Å)
Cite:Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Nat Commun, 12, 2021
6W9G
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Crystal Structure of the Fab fragment of humanized 5c8 antibody containing the fluorescent non-canonical amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine in complex with CD40L at pH 6.8
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 5c8* Fab (heavy chain), ...
Authors:Henderson, J.N, Simmons, C.R, Mills, J.H.
Deposit date:2020-03-23
Release date:2020-12-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural Insights into How Protein Environments Tune the Spectroscopic Properties of a Noncanonical Amino Acid Fluorophore.
Biochemistry, 59, 2020
6X83
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Crystal Structure of TNFalpha with fragment compound 6
Descriptor: 1-benzyl-1H-benzimidazole, Tumor necrosis factor
Authors:Longenecker, K.L, Stoll, V.S.
Deposit date:2020-06-01
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design.
J.Med.Chem., 64, 2021
6X82
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Crystal Structure of TNFalpha with isoquinoline compound 4
Descriptor: 8-[4-(2-{5-[(4-methylpiperazin-1-yl)methyl]-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)phenoxy}ethyl)phenyl]isoquinoline, Tumor necrosis factor
Authors:Longenecker, K.L, Stoll, V.S.
Deposit date:2020-06-01
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design.
J.Med.Chem., 64, 2021
6X86
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Crystal Structure of TNFalpha with indolinone compound 11
Descriptor: 3-[(6-{2-[(3R)-4-(hydroxyacetyl)-3-methylpiperazin-1-yl]pyrimidin-5-yl}-2,2-dimethyl-3-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile, Tumor necrosis factor
Authors:Longenecker, K.L, Stoll, V.S.
Deposit date:2020-06-01
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design.
J.Med.Chem., 64, 2021
6X81
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Crystal Structure of TNFalpha with isoquinoline compound 2
Descriptor: Tumor necrosis factor, [4-(isoquinolin-8-yl)phenyl]acetonitrile
Authors:Longenecker, K.L, Stoll, V.S.
Deposit date:2020-06-01
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design.
J.Med.Chem., 64, 2021
1I9R
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BU of 1i9r by Molmil
STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY
Descriptor: CD40 LIGAND, IMMUNOGLOBULIN H, IMMUNOGLOBULIN L, ...
Authors:Karpusas, M, Lucci, J, Ferrant, J, Benjamin, C, Hsu, Y.-M.
Deposit date:2001-03-20
Release date:2002-03-20
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.
Structure, 9, 2001
1KD7
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BU of 1kd7 by Molmil
Crystal structure of an extracellular domain fragment of human BAFF
Descriptor: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B
Authors:Karpusas, M, Cachero, T.G, Qian, F, Boriack-Sjodin, A, Mullen, C, Strauch, K, Hsu, Y.-M, Kalled, S.L.
Deposit date:2001-11-12
Release date:2002-11-12
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Extracellular Human BAFF, a TNF Family Member that Stimulates B Lymphocytes
J.Mol.Biol., 315, 2002
6X85
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Crystal Structure of TNFalpha with indolinone compound 9
Descriptor: 1-{[2-(difluoromethoxy)phenyl]methyl}-2,2-dimethyl-1,2-dihydro-3H-indol-3-one, Tumor necrosis factor
Authors:Longenecker, K.L, Stoll, V.S.
Deposit date:2020-06-01
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Development of Orally Efficacious Allosteric Inhibitors of TNF alpha via Fragment-Based Drug Design.
J.Med.Chem., 64, 2021
1KXG
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The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.
Descriptor: 1,4-DIETHYLENE DIOXIDE, B lymphocyte stimulator, CITRIC ACID, ...
Authors:Oren, D.A, Li, Y, Volovik, Y, Morris, T.S, Dharia, C, Das, K, Galperina, O, Gentz, R, Arnold, E.
Deposit date:2002-01-31
Release date:2002-03-20
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of BLyS receptor recognition.
Nat.Struct.Biol., 9, 2002
1JH5
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BU of 1jh5 by Molmil
Crystal Structure of sTALL-1 of TNF family ligand
Descriptor: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B
Authors:Liu, Y, Xu, L, Opalka, N, Shu, H.-B, Zhang, G.
Deposit date:2001-06-27
Release date:2002-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.
Cell(Cambridge,Mass.), 108, 2002
1JTZ
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CRYSTAL STRUCTURE OF TRANCE/RANKL CYTOKINE.
Descriptor: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11
Authors:Nelson, C.A, Fremont, D.H.
Deposit date:2001-08-23
Release date:2001-09-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity
J.Clin.Invest., 108, 2001
7KP9
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asymmetric hTNF-alpha
Descriptor: 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor
Authors:Arakaki, T.L, Abendroth, J, Fairman, J.W, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
1IQA
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BU of 1iqa by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MOUSE RANK LIGAND
Descriptor: RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND
Authors:Ito, S, Wakabayashi, K, Ubukata, O, Hayashi, S, Okada, F, Hata, T.
Deposit date:2001-07-11
Release date:2002-03-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.
J.Biol.Chem., 277, 2002
2QDN
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Crystal Structure of mouse GITRL
Descriptor: GITR ligand
Authors:Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
Deposit date:2007-06-21
Release date:2008-01-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QE3
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BU of 2qe3 by Molmil
Crystal structure of human tl1a extracellular domain
Descriptor: CHLORIDE ION, TNF superfamily ligand TL1A
Authors:Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
Deposit date:2007-06-22
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2TNF
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BU of 2tnf by Molmil
1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, PROTEIN (TUMOR NECROSIS FACTOR ALPHA)
Authors:Baeyens, K.J, De Bondt, H.L, Raeymaekers, A, Fiers, W, De Ranter, C.J.
Deposit date:1998-10-12
Release date:1999-10-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization.
Acta Crystallogr.,Sect.D, 55, 1999
2RE9
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Crystal structure of TL1A at 2.1 A
Descriptor: GLYCEROL, MAGNESIUM ION, TNF superfamily ligand TL1A
Authors:Jin, T.C, Guo, F, Kim, S, Howard, A.J, Zhang, Y.Z.
Deposit date:2007-09-25
Release date:2007-10-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of TNF ligand family member TL1A at 2.1 A.
Biochem.Biophys.Res.Commun., 364, 2007
2RJL
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Crystal structure of human TL1A extracellular domain C95S/C135S mutant
Descriptor: TNF superfamily ligand TL1A
Authors:Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
Deposit date:2007-10-15
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009

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