7KP9

asymmetric hTNF-alpha

Summary for 7KP9

Entry DOI	10.2210/pdb7kp9/pdb
Descriptor	Tumor necrosis factor, 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole (3 entities in total)
Functional Keywords	tumour necrosis factor alpha, tnf, asymmetric, protein-protein inhibitor, cytokine
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	52822.70
Authors	Arakaki, T.L.,Abendroth, J.,Fairman, J.W.,Foley, A.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2024-04-03)
Primary citation	McMillan, D.,Martinez-Fleites, C.,Porter, J.,Fox 3rd, D.,Davis, R.,Mori, P.,Ceska, T.,Carrington, B.,Lawson, A.,Bourne, T.,O'Connell, J. Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12:582-582, 2021 Cited by PubMed: 33495441 DOI: 10.1038/s41467-020-20828-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation