2TNF

1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION

Summary for 2TNF

Entry DOI	10.2210/pdb2tnf/pdb
Descriptor	PROTEIN (TUMOR NECROSIS FACTOR ALPHA), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, ... (4 entities in total)
Functional Keywords	lymphokine, cytokine, cytotoxin, transmembrane, glycoprotein, signal-anchor
Biological source	Mus musculus (house mouse)
Cellular location	Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, membrane form: Membrane ; Single-pass type II membrane protein . Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted . C-domain 2: Secreted : P06804
Total number of polymer chains	3
Total formula weight	51999.72
Authors	Baeyens, K.J.,De Bondt, H.L.,Raeymaekers, A.,Fiers, W.,De Ranter, C.J. (deposition date: 1998-10-12, release date: 1999-10-12, Last modification date: 2023-08-30)
Primary citation	Baeyens, K.J.,De Bondt, H.L.,Raeymaekers, A.,Fiers, W.,De Ranter, C.J. The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization. Acta Crystallogr.,Sect.D, 55:772-778, 1999 Cited by PubMed: 10089307 DOI: 10.1107/S0907444998018435 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation