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2TNF

1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE TRS A 1196
ChainResidue
AILE118
ATYR119
AHOH1208
BILE118
BTYR119
BHOH1229
CILE118
CTYR119
CHOH162

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE IPA B 1195
ChainResidue
ATYR119
BTYR119
CTYR119

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPaDGLYLVysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000250
ChainResidueDetails
ASER4
BSER4
CSER4

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN7
BASN7
CASN7

226707

PDB entries from 2024-10-30

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