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3CM9
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BU of 3cm9 by Molmil
Solution Structure of Human SIgA2
Descriptor: Immunoglobulin heavy chain, Immunoglobulin light chain, Secretory component
Authors:Bonner, A, Almogren, A, Furtado, P.B, Kerr, M.A, Perkins, S.J.
Deposit date:2008-03-21
Release date:2008-12-30
Last modified:2024-02-21
Method:SOLUTION SCATTERING
Cite:The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.
J.Biol.Chem., 284, 2009
7CZD
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BU of 7czd by Molmil
Crystal structure of PD-L1 in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ...
Authors:Wang, C.
Deposit date:2020-09-08
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
7BEA
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BU of 7bea by Molmil
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor
Descriptor: 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1
Authors:Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A.
Deposit date:2020-12-22
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
Acs Med.Chem.Lett., 12, 2021
3CSP
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BU of 3csp by Molmil
Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein
Descriptor: Myelin-oligodendrocyte glycoprotein
Authors:Breithaupt, C, Schafer, B, Pellkofer, H, Huber, R, Linington, C, Jacob, U.
Deposit date:2008-04-10
Release date:2008-10-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents
J.Immunol., 181, 2008
3DUR
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BU of 3dur by Molmil
Crystal structure of SAG173-04
Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ...
Authors:Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V.
Deposit date:2008-07-17
Release date:2008-12-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments.
Acta Crystallogr.,Sect.D, 64, 2008
3DUU
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BU of 3duu by Molmil
Crystal structure of SAG506-01, orthorhombic, twinned, crystal 2
Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ...
Authors:Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V.
Deposit date:2008-07-17
Release date:2008-12-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments.
Acta Crystallogr.,Sect.D, 64, 2008
3DV6
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BU of 3dv6 by Molmil
Crystal structure of SAG506-01, tetragonal, crystal 2
Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ...
Authors:Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V.
Deposit date:2008-07-18
Release date:2008-12-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments.
Acta Crystallogr.,Sect.D, 64, 2008
7ELX
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BU of 7elx by Molmil
The crystal structure of CTLA-4 and Fab
Descriptor: Cytotoxic T-lymphocyte protein 4, heavy chain of Fab, light chain of Fab
Authors:Yu, X.J, Wang, L, Yu, C.F.
Deposit date:2021-04-12
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:The crystal structure of CTLA-4 and Fab
To Be Published
7E9B
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BU of 7e9b by Molmil
Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy
Descriptor: Programmed cell death protein 1, heavy chain of Fab fragment of HLX10, light chain of Fab fragment of HLX10
Authors:Fan, S.L, Jiang, W.D.
Deposit date:2021-03-04
Release date:2021-07-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy.
Plos One, 16, 2021
7BXA
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BU of 7bxa by Molmil
Crystal structure of PD-1 in complex with tislelizumab Fab
Descriptor: Programmed cell death protein 1, heavy chain, light chain
Authors:Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B.
Deposit date:2020-04-18
Release date:2020-06-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy.
Biochem.Biophys.Res.Commun., 527, 2020
3DUS
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BU of 3dus by Molmil
Crystal structure of SAG506-01, orthorhombic, twinned, crystal 1
Descriptor: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ...
Authors:Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V.
Deposit date:2008-07-17
Release date:2008-12-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments.
Acta Crystallogr.,Sect.D, 64, 2008
7DV4
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BU of 7dv4 by Molmil
Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4
Descriptor: 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4
Authors:Li, H, Gan, X, He, Y.
Deposit date:2021-01-12
Release date:2022-01-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile.
Proc.Natl.Acad.Sci.USA, 119, 2022
7DY7
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BU of 7dy7 by Molmil
Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation
Descriptor: 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1
Authors:Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B.
Deposit date:2021-01-20
Release date:2022-01-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation.
J.Med.Chem., 65, 2022
6SM1
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BU of 6sm1 by Molmil
Wild type immunoglobulin light chain (WT-1)
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Immunoglobulin lambda variable 2-14, ...
Authors:Kazman, P, Vielberg, M.-T, Cendales, M.D.P, Hunziger, L, Weber, B, Hegenbart, U, Zacharias, M, Koehler, R, Schoenland, S, Groll, M, Buchner, J.
Deposit date:2019-08-21
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation.
Elife, 9, 2020
6U6V
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BU of 6u6v by Molmil
Crystal structure of human PD-1H / VISTA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, V-type immunoglobulin domain-containing suppressor of T-cell activation
Authors:Slater, B.T, Han, X, Chen, L, Xiong, Y.
Deposit date:2019-08-30
Release date:2020-01-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insight into T cell coinhibition by PD-1H (VISTA).
Proc.Natl.Acad.Sci.USA, 117, 2020
6TXZ
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BU of 6txz by Molmil
FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3
Descriptor: Fab H, Fab L, Hepatitis A virus cellular receptor 2
Authors:Musil, D, Sood, V.
Deposit date:2020-01-15
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody.
Oncoimmunology, 9, 2020
6UMV
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BU of 6umv by Molmil
Human apo PD-1 double mutant
Descriptor: CHLORIDE ION, Programmed cell death protein 1
Authors:Tang, S, Kim, P.S.
Deposit date:2019-10-10
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.424 Å)
Cite:A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
6UMT
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BU of 6umt by Molmil
High-affinity human PD-1 PD-L2 complex
Descriptor: MAGNESIUM ION, Programmed cell death 1 ligand 2, Programmed cell death protein 1
Authors:Tang, S, Kim, P.S.
Deposit date:2019-10-10
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
6UMU
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BU of 6umu by Molmil
Human apo PD-1 triple mutant
Descriptor: CHLORIDE ION, Programmed cell death protein 1
Authors:Tang, S, Kim, P.S.
Deposit date:2019-10-10
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.183 Å)
Cite:A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
6V3P
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BU of 6v3p by Molmil
The BIgI domain of beta protein from S. agalactiae bound to CEACAM1
Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, IgA FC receptor, ...
Authors:Bonsor, D.A, McCarthy, A.J.
Deposit date:2019-11-26
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors.
Embo J., 40, 2021
6SRU
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BU of 6sru by Molmil
Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1)
Descriptor: Programmed cell death 1 ligand 1
Authors:Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A.
Deposit date:2019-09-06
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Human and mouse PD-L1: similar molecular structure, but different druggability profiles.
Iscience, 24, 2021
2YZ1
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BU of 2yz1 by Molmil
Crystal structure of the ligand-binding domain of murine SHPS-1/SIRP alpha
Descriptor: Tyrosine-protein phosphatase non-receptor type substrate 1
Authors:Nakaishi, A.
Deposit date:2007-05-02
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47
J.Mol.Biol., 375, 2008
2YWZ
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BU of 2ywz by Molmil
Structure of new antigen receptor variable domain from sharks
Descriptor: new antigen receptor variable domain
Authors:Streltsov, V.A.
Deposit date:2007-04-23
Release date:2007-10-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structures
Proteins, 71, 2007
2ZG2
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BU of 2zg2 by Molmil
Crystal Structure of Two N-terminal Domains of Native Siglec-5
Descriptor: Sialic acid-binding Ig-like lectin 5
Authors:Zhuravleva, M.A, Sun, P.D.
Deposit date:2008-01-17
Release date:2008-02-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural implications of Siglec-5-mediated sialoglycan recognition
J.Mol.Biol., 375, 2008
2Z35
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BU of 2z35 by Molmil
Crystal structure of immune receptor
Descriptor: T-cell receptor alpha-chain, T-cell receptor beta-chain
Authors:Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C.
Deposit date:2007-06-01
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Nat.Immunol., 8, 2007

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