3CM9
| Solution Structure of Human SIgA2 | Descriptor: | Immunoglobulin heavy chain, Immunoglobulin light chain, Secretory component | Authors: | Bonner, A, Almogren, A, Furtado, P.B, Kerr, M.A, Perkins, S.J. | Deposit date: | 2008-03-21 | Release date: | 2008-12-30 | Last modified: | 2024-02-21 | Method: | SOLUTION SCATTERING | Cite: | The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses. J.Biol.Chem., 284, 2009
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7CZD
| Crystal structure of PD-L1 in complex with a VHH | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ... | Authors: | Wang, C. | Deposit date: | 2020-09-08 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
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7BEA
| Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | Deposit date: | 2020-12-22 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
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3CSP
| Crystal structure of the DM2 mutant of myelin oligodendrocyte glycoprotein | Descriptor: | Myelin-oligodendrocyte glycoprotein | Authors: | Breithaupt, C, Schafer, B, Pellkofer, H, Huber, R, Linington, C, Jacob, U. | Deposit date: | 2008-04-10 | Release date: | 2008-10-21 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents J.Immunol., 181, 2008
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3DUR
| Crystal structure of SAG173-04 | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ... | Authors: | Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V. | Deposit date: | 2008-07-17 | Release date: | 2008-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr.,Sect.D, 64, 2008
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3DUU
| Crystal structure of SAG506-01, orthorhombic, twinned, crystal 2 | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ... | Authors: | Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V. | Deposit date: | 2008-07-17 | Release date: | 2008-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr.,Sect.D, 64, 2008
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3DV6
| Crystal structure of SAG506-01, tetragonal, crystal 2 | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ... | Authors: | Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V. | Deposit date: | 2008-07-18 | Release date: | 2008-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr.,Sect.D, 64, 2008
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7ELX
| The crystal structure of CTLA-4 and Fab | Descriptor: | Cytotoxic T-lymphocyte protein 4, heavy chain of Fab, light chain of Fab | Authors: | Yu, X.J, Wang, L, Yu, C.F. | Deposit date: | 2021-04-12 | Release date: | 2021-06-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | The crystal structure of CTLA-4 and Fab To Be Published
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7E9B
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7BXA
| Crystal structure of PD-1 in complex with tislelizumab Fab | Descriptor: | Programmed cell death protein 1, heavy chain, light chain | Authors: | Heo, Y.S, Lee, S.H, Lim, H, Lee, H.T, Kim, Y.J, Park, E.B. | Deposit date: | 2020-04-18 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Crystal structure of PD-1 in complex with an antibody-drug tislelizumab used in tumor immune checkpoint therapy. Biochem.Biophys.Res.Commun., 527, 2020
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3DUS
| Crystal structure of SAG506-01, orthorhombic, twinned, crystal 1 | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, Ig-like protein, MAGNESIUM ION, ... | Authors: | Brooks, C.L, Blackler, R.J, Gerstenbruch, S, Kosma, P, Muller-Loennies, S, Brade, H, Evans, S.V. | Deposit date: | 2008-07-17 | Release date: | 2008-12-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pseudo-symmetry and twinning in crystals of homologous antibody Fv fragments. Acta Crystallogr.,Sect.D, 64, 2008
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7DV4
| Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4 | Descriptor: | 1,2-ETHANEDIOL, 4003-1(VH), Cytotoxic T-lymphocyte protein 4 | Authors: | Li, H, Gan, X, He, Y. | Deposit date: | 2021-01-12 | Release date: | 2022-01-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. Proc.Natl.Acad.Sci.USA, 119, 2022
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7DY7
| Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation | Descriptor: | 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1 | Authors: | Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B. | Deposit date: | 2021-01-20 | Release date: | 2022-01-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem., 65, 2022
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6SM1
| Wild type immunoglobulin light chain (WT-1) | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Immunoglobulin lambda variable 2-14, ... | Authors: | Kazman, P, Vielberg, M.-T, Cendales, M.D.P, Hunziger, L, Weber, B, Hegenbart, U, Zacharias, M, Koehler, R, Schoenland, S, Groll, M, Buchner, J. | Deposit date: | 2019-08-21 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation. Elife, 9, 2020
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6U6V
| Crystal structure of human PD-1H / VISTA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, V-type immunoglobulin domain-containing suppressor of T-cell activation | Authors: | Slater, B.T, Han, X, Chen, L, Xiong, Y. | Deposit date: | 2019-08-30 | Release date: | 2020-01-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insight into T cell coinhibition by PD-1H (VISTA). Proc.Natl.Acad.Sci.USA, 117, 2020
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6TXZ
| FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 | Descriptor: | Fab H, Fab L, Hepatitis A virus cellular receptor 2 | Authors: | Musil, D, Sood, V. | Deposit date: | 2020-01-15 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology, 9, 2020
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6UMV
| Human apo PD-1 double mutant | Descriptor: | CHLORIDE ION, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.424 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMT
| High-affinity human PD-1 PD-L2 complex | Descriptor: | MAGNESIUM ION, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMU
| Human apo PD-1 triple mutant | Descriptor: | CHLORIDE ION, Programmed cell death protein 1 | Authors: | Tang, S, Kim, P.S. | Deposit date: | 2019-10-10 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.183 Å) | Cite: | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc.Natl.Acad.Sci.USA, 116, 2019
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6V3P
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6SRU
| Structure of Ig-like V-type domian of mouse Programmed cell death 1 ligand 1 (PD-L1) | Descriptor: | Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Sala, D, Grudnik, P, Holak, T.A. | Deposit date: | 2019-09-06 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.532 Å) | Cite: | Human and mouse PD-L1: similar molecular structure, but different druggability profiles. Iscience, 24, 2021
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2YZ1
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2YWZ
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2ZG2
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2Z35
| Crystal structure of immune receptor | Descriptor: | T-cell receptor alpha-chain, T-cell receptor beta-chain | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | Deposit date: | 2007-06-01 | Release date: | 2007-10-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon' Nat.Immunol., 8, 2007
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