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5KA3
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Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2016-06-01
Release date:2017-03-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
5KAC
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BU of 5kac by Molmil
Protein Tyrosine Phosphatase 1B P185G mutant, open state
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R.
Deposit date:2016-06-01
Release date:2017-03-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
5J8R
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BU of 5j8r by Molmil
Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 12
Authors:Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P.
Deposit date:2016-04-08
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Crystal structure and substrate specificity of PTPN12.
Cell Rep, 15, 2016
5KA8
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BU of 5ka8 by Molmil
Protein Tyrosine Phosphatase 1B L192A mutant, open state
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2016-06-01
Release date:2017-03-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.971 Å)
Cite:Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
5KA1
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BU of 5ka1 by Molmil
Protein Tyrosine Phosphatase 1B Delta helix 7 mutant in complex with TCS401, closed state
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Choy, M.S, Peti, W, Page, R.
Deposit date:2016-06-01
Release date:2017-03-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
6CWV
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BU of 6cwv by Molmil
Protein Tyrosine Phosphatase 1B A122S mutant
Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Hjortness, M, Zwart, P, Sankaran, B, Fox, J.M.
Deposit date:2018-03-31
Release date:2018-10-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98002291 Å)
Cite:Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases.
Biochemistry, 57, 2018
7KEN
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BU of 7ken by Molmil
Protein Tyrosine Phosphatase 1B, D289A mutant, apo state
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Fox, J.M, Hongdusit, A.
Deposit date:2020-10-11
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases.
Biochemistry, 60, 2021
6D3F
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BU of 6d3f by Molmil
Crystal Structure of the PTP epsilon D2 domain
Descriptor: Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-16
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6CWU
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BU of 6cwu by Molmil
Protein Tyrosine Phosphatase 1B F135Y mutant
Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Hjortness, M, Zwart, P, Sankaran, B, Fox, J.M.
Deposit date:2018-03-31
Release date:2018-10-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases.
Biochemistry, 57, 2018
7KEY
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BU of 7key by Molmil
Protein Tyrosine Phosphatase 1B, Apo
Descriptor: ACETATE ION, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Battaile, K.P, Chirgadze, Y, Ruzanov, M, Romanov, V, Lam, K, Gordon, R, Lin, A, Lam, R, Pai, E, Chirgadze, N.
Deposit date:2020-10-13
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.771 Å)
Cite:Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058.
J.Biomol.Struct.Dyn., 2021
7KLX
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BU of 7klx by Molmil
Protein Tyrosine Phosphatase 1B with inhibitor
Descriptor: 2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Battaile, K.P, Chirgadze, Y, Ruzanov, M, Romanov, V, Lam, K, Gordon, R, Lin, A, Lam, R, Pai, E, Chirgadze, N.
Deposit date:2020-11-01
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.839 Å)
Cite:Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058.
J.Biomol.Struct.Dyn., 2021
6D4F
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BU of 6d4f by Molmil
Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D)
Descriptor: PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6D4D
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BU of 6d4d by Molmil
Crystal structure of the PTP epsilon D1 domain
Descriptor: Receptor-type tyrosine-protein phosphatase epsilon
Authors:Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S.
Deposit date:2018-04-18
Release date:2018-10-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.765 Å)
Cite:High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Acta Crystallogr D Struct Biol, 74, 2018
6DR1
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BU of 6dr1 by Molmil
YopH PTP1B Chimera 2 PTPase
Descriptor: Targeted effector protein
Authors:Morales, Y, Johnson, S.J, Hengge, A.C.
Deposit date:2018-06-11
Release date:2018-08-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases.
Biochemistry, 57, 2018
6DR7
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BU of 6dr7 by Molmil
YopH PTP1B WPD loop Chimera 2 PTPase bound to vanadate
Descriptor: ACETATE ION, Targeted effector protein, VANADATE ION
Authors:Moise, G, Morales, Y, Johnson, S.J, Hengge, A.C.
Deposit date:2018-06-11
Release date:2018-08-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases.
Biochemistry, 57, 2018
7MM1
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BU of 7mm1 by Molmil
PTP1B in complex with TCS401 by Native S-SAD at Room Temperature
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Greisman, J.B, Dalton, K.M, Hekstra, D.R.
Deposit date:2021-04-29
Release date:2021-05-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Native SAD phasing at room temperature.
Acta Crystallogr D Struct Biol, 78, 2022
7MNB
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BU of 7mnb by Molmil
PTP1B F225Y-R199N-L195R in complex with TCS401
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, GLYCEROL, ...
Authors:Torgeson, K.R, Page, R, Peti, W.
Deposit date:2021-04-30
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOW
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BU of 7mow by Molmil
PTP1B F225I in complex with TCS401
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Torgeson, K.R, Page, R, Peti, W.
Deposit date:2021-05-03
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOU
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BU of 7mou by Molmil
PTP1B F225Y-R199N-L195R
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Torgeson, K.R, Page, R, Peti, W.
Deposit date:2021-05-03
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MKZ
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BU of 7mkz by Molmil
PTP1B F225Y mutant, open state
Descriptor: CHLORIDE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Torgeson, K.R, Page, R, Peti, W.
Deposit date:2021-04-27
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7MOV
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BU of 7mov by Molmil
PTP1B 1-301 F225Y-R199N mutations
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Torgeson, K.R, Page, R, Peti, W.
Deposit date:2021-05-03
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8, 2022
7LFO
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BU of 7lfo by Molmil
Protein Tyrosine Phosphatase 1B
Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1
Authors:Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J.M.
Deposit date:2021-01-18
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products.
Acs Synth Biol, 10, 2021
7L0C
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BU of 7l0c by Molmil
Ligand-free PTP1B T177G
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Shen, R.D, Hengge, A.C, Johnson, S.J.
Deposit date:2020-12-11
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
7L0M
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BU of 7l0m by Molmil
Vanadate-bound YopH G352T
Descriptor: Protein-tyrosine-phosphatase, VANADATE ION
Authors:Shen, R.D, Hengge, A.C, Johnson, S.J.
Deposit date:2020-12-11
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
7L0I
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BU of 7l0i by Molmil
Ligand-free YopH G352T
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein-tyrosine-phosphatase
Authors:Shen, R.D, Hengge, A.C, Johnson, S.J.
Deposit date:2020-12-11
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021

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PDB entries from 2024-09-18

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