7KLX

Protein Tyrosine Phosphatase 1B with inhibitor

Summary for 7KLX

• Entry DOI: 10.2210/pdb7klx/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 1, 2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: insulin, regulation, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33058.13

Authors

Battaile, K.P.,Chirgadze, Y.,Ruzanov, M.,Romanov, V.,Lam, K.,Gordon, R.,Lin, A.,Lam, R.,Pai, E.,Chirgadze, N. (deposition date: 2020-11-01, release date: 2022-01-19, Last modification date: 2023-10-18)

• Primary citation: Chirgadze, Y.N.,Battaile, K.P.,Likhachev, I.V.,Balabaev, N.K.,Gordon, R.D.,Romanov, V.,Lin, A.,Karisch, R.,Lam, R.,Ruzanov, M.,Brazhnikov, E.V.,Pai, E.F.,Neel, B.G.,Chirgadze, N.Y.; Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058.; J.Biomol.Struct.Dyn., :1-10, 2021; PubMed: 34705594; DOI: 10.1080/07391102.2021.1994879

Experimental method

X-RAY DIFFRACTION (1.839 Å)