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7MNB

PTP1B F225Y-R199N-L195R in complex with TCS401

Summary for 7MNB
Entry DOI10.2210/pdb7mnb/pdb
DescriptorTyrosine-protein phosphatase non-receptor type 1, 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsprotein tyrosine phosphatase, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight36487.78
Authors
Torgeson, K.R.,Page, R.,Peti, W. (deposition date: 2021-04-30, release date: 2022-05-18, Last modification date: 2023-10-18)
Primary citationTorgeson, K.R.,Clarkson, M.W.,Granata, D.,Lindorff-Larsen, K.,Page, R.,Peti, W.
Conserved conformational dynamics determine enzyme activity.
Sci Adv, 8:eabo5546-eabo5546, 2022
Cited by
PubMed: 35921420
DOI: 10.1126/sciadv.abo5546
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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