7MNB
PTP1B F225Y-R199N-L195R in complex with TCS401
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 308 | 35813.7 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | A | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID | non-polymer | 270.3 | 1 | Chemie (OTA) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 1 - 301 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 195 | Leu 195 | engineered mutation |
| Asn 199 | Arg 199 | engineered mutation |
| Tyr 225 | Phe 225 | engineered mutation |
| His 302 | - | expression tag |
| Asn 303 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35813.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 674.1 | |
| All* | Total formula weight | 36487.8 |
