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2KTY
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BU of 2kty by Molmil
Solution Structure of human Vaccinia Related Kinase-1
Descriptor: Serine/threonine-protein kinase VRK1
Authors:Shin, J, Yoon, H.
Deposit date:2010-02-10
Release date:2011-02-16
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution Structure of human Vaccinia-Related Kinase 1
To be Published
2KUL
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BU of 2kul by Molmil
Solution structure of human vaccinia related kinase 1(VRK1)
Descriptor: Serine/threonine-protein kinase VRK1
Authors:Shin, J, Yoon, H.
Deposit date:2010-02-19
Release date:2011-02-23
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of human vaccinia related kinase 1(VRK1)
To be Published
2LGC
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BU of 2lgc by Molmil
Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution
Descriptor: Mitogen-activated protein kinase 14
Authors:Habeck, M.
Deposit date:2011-07-25
Release date:2012-07-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38alpha MAP kinase complex in solution
Angew.Chem.Int.Ed.Engl., 51, 2012
1R0E
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BU of 1r0e by Molmil
Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor
Descriptor: 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, CITRATE ANION, Glycogen synthase kinase-3 beta
Authors:Allard, J, Nikolcheva, T, Gong, L, Wang, J, Dunten, P, Avnur, Z, Waters, R, Sun, Q, Skinner, B.
Deposit date:2003-09-20
Release date:2004-10-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:From genetics to therapeutics: the Wnt pathway and osteoporosis
To be Published
1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
1Q8T
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BU of 1q8t by Molmil
The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632
Descriptor: (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Breitenlechner, C, Gassel, M, Hidaka, H, Kinzel, V, Huber, R, Engh, R.A, Bossemeyer, D.
Deposit date:2003-08-22
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Structure, 11, 2003
1Q8Z
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BU of 1q8z by Molmil
The apoenzyme structure of the yeast SR protein kinase, Sky1p
Descriptor: 1,2-ETHANEDIOL, METHANOL, SR Protein Kinase, ...
Authors:Nolen, B, Ngo, J, Chakrabarti, S, Vu, D, Adams, J.A, Ghosh, G.
Deposit date:2003-08-22
Release date:2003-09-23
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Nucleotide-Induced Conformational Changes in the Saccharomyces cerevisiae SR Protein Kinase, Sky1p, Revealed by X-Ray Crystallography
Biochemistry, 42, 2003
5FRI
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BU of 5fri by Molmil
ALK5 in complex witha an N-(4-anilino-2-pyridyl)acetamide inhibitor.
Descriptor: 1,2-ETHANEDIOL, N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide, TGF-BETA RECEPTOR TYPE-1
Authors:Goldberg, F.W, Daunt, P, Pearson, S.E, Greenwood, R, Debreczeni, J, Grist, M.
Deposit date:2015-12-17
Release date:2016-07-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and optimisation of a series of N-(4-anilino-2-pyridyl)acetamide activin receptor-like kinase 1 (ALK1) inhibitors
Med. Chem. Commun., 7, 2016
4UJ1
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BU of 4uj1 by Molmil
Protein Kinase A in complex with an Inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ...
Authors:Alam, K.A, Engh, R.A.
Deposit date:2015-04-07
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.768 Å)
Cite:Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic.
Chemistry, 22, 2016
2A0C
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BU of 2a0c by Molmil
Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Descriptor: 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL, Cell division protein kinase 2
Authors:Krystof, V, McNae, I.W, Walkinshaw, M.D, Fischer, P.M, Muller, P, Vojtesek, B, Orsag, M, Havlicek, L, Strnad, M.
Deposit date:2005-06-16
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Cell.Mol.Life Sci., 62, 2005
7OAJ
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BU of 7oaj by Molmil
Crystal structure of pseudokinase CASK in complex with compound 7
Descriptor: 1,2-ETHANEDIOL, 4-(cyclopentylamino)-2-[(3,4-dichlorophenyl)methylamino]-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAI
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BU of 7oai by Molmil
Crystal structure of pseudokinase CASK in complex with PFE-PKIS12
Descriptor: 1,2-ETHANEDIOL, 4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAK
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BU of 7oak by Molmil
Crystal structure of pseudokinase CASK in complex with compound 26
Descriptor: 1,2-ETHANEDIOL, 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclopentylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
7OAL
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BU of 7oal by Molmil
Crystal structure of pseudokinase CASK in complex with compound 25
Descriptor: 1,2-ETHANEDIOL, 2-[[2,5-bis(bromanyl)-4-methyl-phenyl]methylamino]-4-(cyclohexylamino)-N-[3-(2-oxidanylidene-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, Peripheral plasma membrane protein CASK
Authors:Chaikuad, A, Russ, N, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-04-19
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase.
J.Med.Chem., 64, 2021
4USE
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BU of 4use by Molmil
Human STK10 (LOK) with SB-633825
Descriptor: 4-{5-(6-methoxynaphthalen-2-yl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl}pyridine, SERINE/THREONINE-PROTEIN KINASE 10
Authors:Elkins, J.M, Salah, E, Szklarz, M, von Delft, F, Canning, P, Raynor, J, Bountra, C, Edwards, A.M, Knapp, S.
Deposit date:2014-07-07
Release date:2015-07-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Comprehensive Characterization of the Published Kinase Inhibitor Set.
Nat.Biotechnol., 34, 2016
1ZYD
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BU of 1zyd by Molmil
Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type Complexed with ATP.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase GCN2
Authors:Padyana, A.K, Qiu, H, Roll-Mecak, A, Hinnebusch, A.G, Burley, S.K.
Deposit date:2005-06-09
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2
J.Biol.Chem., 280, 2005
7NVQ
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BU of 7nvq by Molmil
Aerosol-soaked human cdk2 crystals with Staurosporine
Descriptor: 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, STAUROSPORINE
Authors:Ross, B, Huber, R.
Deposit date:2021-03-15
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Aerosol-based ligand soaking of reservoir-free protein crystals.
J.Appl.Crystallogr., 54, 2021
2A4L
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BU of 2a4l by Molmil
Human cyclin-dependent kinase 2 in complex with roscovitine
Descriptor: Homo sapiens cyclin-dependent kinase 2, R-ROSCOVITINE
Authors:De Azevedo Jr, W.F, Kim, S.H.
Deposit date:2005-06-29
Release date:2006-10-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine.
Eur.J.Biochem., 243, 1997
2AC3
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BU of 2ac3 by Molmil
Structure of human Mnk2 Kinase Domain
Descriptor: MAP kinase-interacting serine/threonine kinase 2, ZINC ION
Authors:Jauch, R, Wahl, M.C, Netter, C, Jakel, S, Schreiter, K, Aicher, B, Jackle, H.
Deposit date:2005-07-18
Release date:2005-10-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Structure, 13, 2005
2AC5
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BU of 2ac5 by Molmil
Structure of human Mnk2 Kinase Domain mutant D228G
Descriptor: MAP kinase-interacting serine/threonine kinase 2, ZINC ION
Authors:Jauch, R, Wahl, M.C, Jakel, S, Schreiter, K, Aicher, B, Jackle, H.
Deposit date:2005-07-18
Release date:2005-10-04
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Structure, 13, 2005
2A2A
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BU of 2a2a by Molmil
High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, Death-associated protein kinase 2, ...
Authors:Kursula, P, Wilmanns, M.
Deposit date:2005-06-22
Release date:2006-10-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites
Structure, 2016
4W4X
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BU of 4w4x by Molmil
JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Descriptor: 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
Authors:Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W8D
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BU of 4w8d by Molmil
Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06454589).
Descriptor: 5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine, Serine/threonine-protein kinase 24 36 kDa subunit
Authors:Jasti, J, Song, X, Griffor, M, Kurumbail, R.G.
Deposit date:2014-08-24
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J.Med.Chem., 58, 2015
4W7P
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BU of 4w7p by Molmil
Crystal Structure of ROCK 1 bound to YB-15-QD37
Descriptor: N~1~-[2-(1H-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine, Rho-associated protein kinase 1
Authors:Sprague, E.R.
Deposit date:2014-08-22
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Bioorg.Med.Chem.Lett., 24, 2014
4W8E
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Structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06645342)
Descriptor: 3-{4-[(2R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile, Serine/threonine-protein kinase 24 36 kDa subunit
Authors:Jasti, J, Song, X, Griffor, M, Kurumbail, R.G.
Deposit date:2014-08-24
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J.Med.Chem., 58, 2015

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数据于2024-09-18公开中

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