5FRI

ALK5 in complex witha an N-(4-anilino-2-pyridyl)acetamide inhibitor.

Summary for 5FRI

• Entry DOI: 10.2210/pdb5fri/pdb
• Related: 5FQP 5FQR 5FQS 5FQT 5FQV
• Descriptor: TGF-BETA RECEPTOR TYPE-1, 1,2-ETHANEDIOL, N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 34836.38

Authors

Goldberg, F.W.,Daunt, P.,Pearson, S.E.,Greenwood, R.,Debreczeni, J.,Grist, M. (deposition date: 2015-12-17, release date: 2016-07-27, Last modification date: 2019-05-08)

• Primary citation: Goldberg, F.W.,Daunt, P.,Pearson, S.E.,Greenwood, R.,Debreczeni, J.,Grist, M.; Identification and optimisation of a series of N-(4-anilino-2-pyridyl)acetamide activin receptor-like kinase 1 (ALK1) inhibitors; Med. Chem. Commun., 7:1204-1208, 2016; DOI: 10.1039/C6MD00039H

Experimental method

X-RAY DIFFRACTION (2 Å)