5FRI
ALK5 in complex witha an N-(4-anilino-2-pyridyl)acetamide inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TGF-BETA RECEPTOR TYPE-1 | polymer | 301 | 34379.5 | 1 | UniProt (P36897) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | TGFR-1, ALK5, ACTIVIN A RECEPTOR TYPE II-LIKE PROTEIN KINASE OF 53KD, ACTIVIN RECEPTOR-LIKE KINASE 5, ALK-5, ALK5, SERINE/THREONINE-PROTEIN KINASE RECEPTOR R4, SKR4, TGF-BETA TYPE I RECEPTOR, TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I, TGF-BETA RECEPTOR TYPE I, TBETAR-I |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 3 | A | N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | non-polymer | 332.7 | 1 | Chemie (ZUQ) | |||
| 4 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 200 - 498 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Gly 198 | - | expression tag |
| Gly 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34379.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 456.9 | |
| All* | Total formula weight | 34836.4 |
