5FQP
Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 1.
Summary for 5FQP
Entry DOI | 10.2210/pdb5fqp/pdb |
Related | 5FQR 5FQS 5FQT 5FQV |
Descriptor | ESTROGEN RECEPTOR ALPHA, (E)-3-[4-[(1R,3R)-6-hydroxy-2-isobutyl-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid (3 entities in total) |
Functional Keywords | signaling protein, breast cancer, estrogen receptor downregulator, fulvestrant, thiq, nuclear hormone receptor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 28623.58 |
Authors | Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. (deposition date: 2015-12-14, release date: 2016-02-10, Last modification date: 2024-05-08) |
Primary citation | Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7:94-, 2016 Cited by PubMed: 26819673DOI: 10.1021/ACSMEDCHEMLETT.5B00413 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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