5FQP
Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ESTROGEN RECEPTOR ALPHA | polymer | 248 | 28258.1 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | HOMO SAPIENS (HUMAN) | ER, ER-ALPHA, ESTRADIOL RECEPTOR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP A MEMBER 1, ESTROGEN RECEPTOR ALPHA |
| 2 | A | (E)-3-[4-[(1R,3R)-6-hydroxy-2-isobutyl-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid | non-polymer | 365.5 | 1 | Chemie (GQD) | |||
| 3 | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 307 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28258.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.5 | |
| All* | Total formula weight | 28623.6 |
