2LGC
Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution
Summary for 2LGC
Entry DOI | 10.2210/pdb2lgc/pdb |
NMR Information | BMRB: 6468 |
Descriptor | Mitogen-activated protein kinase 14 (1 entity in total) |
Functional Keywords | p38 mapk kinase-inhibitor complex, hybrid nmr/x-ray structure, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41208.14 |
Authors | Habeck, M. (deposition date: 2011-07-25, release date: 2012-07-25, Last modification date: 2024-05-15) |
Primary citation | Honndorf, V.S.,Coudevylle, N.,Laufer, S.,Becker, S.,Griesinger, C.,Habeck, M. Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38alpha MAP kinase complex in solution Angew.Chem.Int.Ed.Engl., 51:2359-2362, 2012 Cited by PubMed: 22275118DOI: 10.1002/anie.201105241 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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