7OAI

Crystal structure of pseudokinase CASK in complex with PFE-PKIS12

Summary for 7OAI

Entry DOI	10.2210/pdb7oai/pdb
Descriptor	Peripheral plasma membrane protein CASK, 4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	pseudokinase, kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	161230.72
Authors	Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-04-19, release date: 2021-05-19, Last modification date: 2024-01-31)
Primary citation	Russ, N.,Schroder, M.,Berger, B.T.,Mandel, S.,Aydogan, Y.,Mauer, S.,Pohl, C.,Drewry, D.H.,Chaikuad, A.,Muller, S.,Knapp, S. Design and Development of a Chemical Probe for Pseudokinase Ca 2+ /calmodulin-Dependent Ser/Thr Kinase. J.Med.Chem., 64:14358-14376, 2021 Cited by PubMed: 34543009 DOI: 10.1021/acs.jmedchem.1c00845 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation