7OAI

Crystal structure of pseudokinase CASK in complex with PFE-PKIS12

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue V5W A 401

Chain	Residue
A	ILE18
A	LEU148
A	GLY161
A	GLY162
A	HOH593
A	ALA39
A	GLU92
A	MET94
A	ASP95
A	GLY96
A	ALA97
A	LYS105
A	CYS146

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 402

Chain	Residue
A	ARG28
A	ILE30
A	EDO403
D	HIS287

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 403

Chain	Residue
A	GLU13
A	EDO402
D	LYS285

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	SER24
A	LYS41
A	VAL43
A	GLU62
A	HOH564

---

site_id	AC5
Number of Residues	2
Details	binding site for residue EDO A 405

Chain	Residue
A	HIS287
D	ARG28

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	ASP134
A	HOH505
A	HOH518
D	ASP251
D	ARG254

---

site_id	AC7
Number of Residues	12
Details	binding site for residue V5W B 401

Chain	Residue
B	ILE18
B	GLY19
B	ALA39
B	GLU92
B	MET94
B	ASP95
B	GLY96
B	LYS105
B	CYS146
B	LEU148
B	GLY161
B	GLY162

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO B 402

Chain	Residue
B	SER24
B	LYS41
B	PHE48
B	GLU62
B	HOH551

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO B 403

Chain	Residue
B	CYS15
B	ARG28
C	HIS287

---

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO B 404

Chain	Residue
B	ILE18

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO B 405

Chain	Residue
B	GLU171
B	LYS234

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO B 406

Chain	Residue
B	CYS216
B	LEU217
B	TYR220
B	ARG301

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO B 407

Chain	Residue
B	ARG255
B	MET258
B	GLU263
B	ILE265
C	ASP134
C	LYS234

---

site_id	AD5
Number of Residues	15
Details	binding site for residue V5W C 401

Chain	Residue
C	ILE18
C	GLY19
C	ALA39
C	PHE91
C	GLU92
C	PHE93
C	MET94
C	ASP95
C	GLY96
C	LYS105
C	CYS146
C	LEU148
C	GLY161
C	GLY162
C	HOH526

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO C 402

Chain	Residue
B	ASP251
B	PRO274
C	GLU171
C	LYS234

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO C 403

Chain	Residue
B	LYS285
C	GLU13
C	EDO404

---

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO C 404

Chain	Residue
C	CYS15
C	ARG28
C	ILE30
C	EDO403

---

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO C 405

Chain	Residue
C	LYS41
C	VAL43
C	LEU59
C	GLU62

---

site_id	AE1
Number of Residues	15
Details	binding site for residue V5W D 401

Chain	Residue
D	PHE93
D	MET94
D	ASP95
D	GLY96
D	ALA97
D	LYS105
D	CYS146
D	LEU148
D	LYS152
D	GLY161
D	GLY162
D	ILE18
D	GLY19
D	ALA39
D	GLU92

---

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO D 402

Chain	Residue
A	ASP134
D	ARG255
D	MET258
D	GLU263
D	ILE265

---

site_id	AE3
Number of Residues	1
Details	binding site for residue EDO D 403

Chain	Residue
D	ILE18

---

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO D 404

Chain	Residue
D	LYS41
D	PHE48
D	GLU62

---

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO D 405

Chain	Residue
D	CYS216
D	LEU217
D	TYR220
D	ARG301

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1056
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00100","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"18423203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O70589","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---