Summary for 4W8D
| Related | 4W8E |
|---|---|
| Descriptor | Serine/threonine-protein kinase 24 36 kDa subunit, 5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (3 entities in total) |
| Functional Keywords | mst3, pyrrolopyrimidine, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm Q9Y6E0 |
| Total number of polymer chains | 1 |
| Total molecular weight | 33239.09 |
| Authors | Jasti, J.,Song, X.,Griffor, M.,Kurumbail, R.G. (deposition date: 2014-08-24, release date: 2015-03-18) |
| Primary citation | Henderson, J.L.,Kormos, B.L.,Hayward, M.M.,Coffman, K.J.,Jasti, J.,Kurumbail, R.G.,Wager, T.T.,Verhoest, P.R.,Noell, G.S.,Chen, Y.,Needle, E.,Berger, Z.,Steyn, S.J.,Houle, C.,Hirst, W.D.,Galatsis, P. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem., 58:419-432, 2015 PubMed: 25353650 (PDB entries with the same primary citation) DOI: 10.1021/jm5014055  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.77 Å) |
