4A24
| Structural and functional analysis of the DEAF-1 and BS69 MYND domains | Descriptor: | DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG, ZINC ION | Authors: | Kateb, F, Perrin, H, Tripsianes, K, Zou, P, Spadaccini, R, Bottomley, M, Bepperling, A, Ansieau, S, Sattler, M. | Deposit date: | 2011-09-22 | Release date: | 2012-11-07 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and Functional Analysis of the Deaf-1 and Bs69 Mynd Domains. Plos One, 8, 2013
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2JW6
| Solution structure of the DEAF1 MYND domain | Descriptor: | Deformed epidermal autoregulatory factor 1 homolog, ZINC ION | Authors: | Spadaccini, R, Perrin, H, Bottomley, M, Ansieu, S, Sattler, M. | Deposit date: | 2007-10-08 | Release date: | 2007-12-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Retraction notice to "Structure and functional analysis of the MYND domain" [J. Mol. Biol. (2006) 358, 498-508]. J.Mol.Biol., 376, 2008
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2ODD
| Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor | Descriptor: | Protein CBFA2T1, SMRT, ZINC ION | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | Deposit date: | 2006-12-22 | Release date: | 2007-06-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell, 11, 2007
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2OD1
| Solution structure of the MYND domain from human AML1-ETO | Descriptor: | Protein CBFA2T1, ZINC ION | Authors: | Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H. | Deposit date: | 2006-12-21 | Release date: | 2007-06-19 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell, 11, 2007
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2DAN
| The solution structure of the MYND domain (LEU384-CYS430) of human Zinc finger MYND domain containing protein 10 | Descriptor: | ZINC ION, Zinc finger MYND domain containing protein 10 | Authors: | Sasagawa, A, Miyamoto, K, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-14 | Release date: | 2006-06-14 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of the MYND domain (LEU384-CYS430) of human
Zinc finger MYND domain containing protein 10 To be Published
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2D8Q
| Solution structure of the MYND domain of the human zinc finger MYND domain-containing protein 10 | Descriptor: | ZINC ION, Zinc finger MYND domain containing protein 10 | Authors: | Miyamoto, K, Kigawa, T, Tomizawa, T, Tochio, N, Sasagawa, A, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-08 | Release date: | 2006-06-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the MYND domain of the human zinc finger MYND domain-containing protein 10 To be Published
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2DJ8
| Solution Structure of zf-MYND Domain of Protein CBFA2TI (Protein MTG8) | Descriptor: | Protein CBFA2T1, ZINC ION | Authors: | Niraula, T.N, Sasagawa, A, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-03-31 | Release date: | 2006-10-01 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of zf-MYND Domain of Protein CBFA2TI (Protein MTG8) To be published
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6PAF
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7O2C
| X-RAY STRUCTURE OF SMYD3 IN COMPLEX WITH the benzodiazepine-based probe BAY-6035 | Descriptor: | (2S)-1-[[(1R,5S)-3-azabicyclo[3.1.0]hexan-3-yl]carbonyl]-N-(2-cyclopropylethyl)-2-methyl-4-oxidanylidene-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... | Authors: | Steuber, H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. Slas Discov, 26, 2021
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3RU0
| Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound | Descriptor: | SET and MYND domain-containing protein 3, SINEFUNGIN, ZINC ION | Authors: | Foreman, K.W, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P. | Deposit date: | 2011-05-04 | Release date: | 2011-05-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3. Plos One, 6, 2011
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6IJL
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4WUY
| Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor | Descriptor: | 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ... | Authors: | Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M. | Deposit date: | 2014-11-04 | Release date: | 2015-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J.Biol.Chem., 290, 2015
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8OWO
| SMYD3 in complex with fragment FL01507 | Descriptor: | 3-oxidanylbenzenecarbonitrile, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | Authors: | Lund, B.A, Cederfelt, D, Dobritzsch, D. | Deposit date: | 2023-04-28 | Release date: | 2023-08-30 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening. Rsc Med Chem, 15, 2024
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3MEK
| Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine | Descriptor: | S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ZINC ION | Authors: | Lam, R, Dombrovski, L, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-03-31 | Release date: | 2010-04-14 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine To be Published
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4O6F
| Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2 | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Estrogen receptor, N-lysine methyltransferase SMYD2, ... | Authors: | Jiang, Y, Trescott, L, Holcomb, J, Brunzelle, J, Sirinupong, N, Shi, X, Yang, Z. | Deposit date: | 2013-12-20 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.822 Å) | Cite: | Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation. J.Mol.Biol., 426, 2014
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8J07
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7BJ1
| Crystal structure of SMYD3 with diperodon S enantiomer bound to allosteric site | Descriptor: | ACETATE ION, Diperodon (S-enantiomer), GLYCEROL, ... | Authors: | Talibov, V.O, Cederfelt, D, Dobritzsch, D, Danielson, U.H. | Deposit date: | 2021-01-13 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase Chembiochem, 22, 2021
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6N3G
| Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol | Descriptor: | DODECAETHYLENE GLYCOL, ETHANOL, N-lysine methyltransferase SMYD2, ... | Authors: | Perry, E, Spellmon, N, Brunzelle, J, Yang, Z. | Deposit date: | 2018-11-15 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol To be Published
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7O2A
| X-RAY STRUCTURE OF SMYD3 IN COMPLEX WITH benzodiazepine-type inhibitor compound 15 | Descriptor: | (2S)-1-(4-azanylpiperidin-1-yl)carbonyl-N-(2-cyclopropylethyl)-2-methyl-4-oxidanylidene-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... | Authors: | Steuber, H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. Slas Discov, 26, 2021
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7O2B
| X-RAY STRUCTURE OF SMYD3 in complex with benzodiazepine-type inhibitor 6 | Descriptor: | (2S)-N-butyl-1-(2-fluorophenyl)carbonyl-2-methyl-4-oxidanylidene-3,5-dihydro-2H-1,5-benzodiazepine-7-carboxamide, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... | Authors: | Steuber, H. | Deposit date: | 2021-03-30 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening. Slas Discov, 26, 2021
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6MON
| Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor | Descriptor: | GLYCEROL, LYS-LEU-NLE-SER-LYS-ARG-GLY, N-lysine methyltransferase SMYD2, ... | Authors: | Spellmon, N, Cornett, E, Brunzelle, J, Rothbart, S, Yang, Z. | Deposit date: | 2018-10-04 | Release date: | 2018-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.711 Å) | Cite: | A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity. Sci Adv, 4, 2018
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6YUH
| Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site | Descriptor: | Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | Authors: | Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. | Deposit date: | 2020-04-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
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5HI7
| Co-crystal structure of human SMYD3 with an aza-SAH compound | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl][3-(dimethylamino)propyl]amino}-5'-deoxyadenosine, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SMYD3, ... | Authors: | Elkins, P.A, Bonnette, W.G. | Deposit date: | 2016-01-11 | Release date: | 2016-03-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure, 24, 2016
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6CBX
| Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, N-lysine methyltransferase SMYD2, ... | Authors: | ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | Deposit date: | 2018-02-05 | Release date: | 2018-03-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497 to be published
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6O9O
| Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 | Descriptor: | 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... | Authors: | Elkins, P.A, Wang, L. | Deposit date: | 2019-03-14 | Release date: | 2020-03-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.586 Å) | Cite: | Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
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