6MON
Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor
Summary for 6MON
Entry DOI | 10.2210/pdb6mon/pdb |
Descriptor | N-lysine methyltransferase SMYD2, LYS-LEU-NLE-SER-LYS-ARG-GLY, ZINC ION, ... (6 entities in total) |
Functional Keywords | methyltransferase, norleucine, complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 101548.56 |
Authors | Spellmon, N.,Cornett, E.,Brunzelle, J.,Rothbart, S.,Yang, Z. (deposition date: 2018-10-04, release date: 2018-12-12, Last modification date: 2023-11-15) |
Primary citation | Cornett, E.M.,Dickson, B.M.,Krajewski, K.,Spellmon, N.,Umstead, A.,Vaughan, R.M.,Shaw, K.M.,Versluis, P.P.,Cowles, M.W.,Brunzelle, J.,Yang, Z.,Vega, I.E.,Sun, Z.W.,Rothbart, S.B. A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity. Sci Adv, 4:eaav2623-eaav2623, 2018 Cited by PubMed: 30498785DOI: 10.1126/sciadv.aav2623 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.711 Å) |
Structure validation
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