6MON
Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase SMYD2 | polymer | 429 | 49343.6 | 2 | UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (Human) | HSKM-B,Histone methyltransferase SMYD2,Lysine N-methyltransferase 3C,SET and MYND domain-containing protein 2 |
| 2 | C, D (C, D) | LYS-LEU-NLE-SER-LYS-ARG-GLY | polymer | 7 | 804.0 | 2 | synthetic construct | ||
| 3 | E, F, G, J, K... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | H, M (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 5 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 433 (UniProt: Q9NRG4)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | Gly 165 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 100295.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1253.4 | |
| All* | Total formula weight | 101548.6 |
