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7AZB
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Structure of DDR2 DS domain in complex with VHH
分子名称: Discoidin domain-containing receptor 2, VHH
著者Talagas, A, Nawrotek, A, Arrial, A, Vuillard, L.M, Miallau, L.
登録日2020-11-16
公開日2020-11-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structure of DDR2 DS domain in complex with VHH
To Be Published
7S0P
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Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
分子名称: Coagulation factor VIII, PHOSPHOSERINE
著者Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C.
登録日2021-08-30
公開日2021-10-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Front Mol Biosci, 9, 2022
3NNG
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BU of 3nng by Molmil
Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis. Northeast Structural Genomics Consortium Target BfR258E
分子名称: CALCIUM ION, uncharacterized protein
著者Vorobiev, S, Su, M, Dimaio, F, Baker, D, Seetharaman, J, Janjua, J, Xiao, R, Ciccosanti, C, Foote, E.L, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2010-06-23
公開日2010-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis.
To be Published
5Y4M
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Discoidin domain of human CASPR2
分子名称: 1,2-ETHANEDIOL, human CASPR2 Disc domain
著者Liu, H, Xu, F, Zhang, J, Liang, W.
登録日2017-08-04
公開日2018-08-08
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.
J. Autoimmun., 96, 2019
4XZU
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Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
分子名称: 3E6 antibody Fab heavy chain, 3E6 antibody Fab light chain, Coagulation factor VIII, ...
著者Spiegel, P.C, Wuerth, M.E.
登録日2015-02-05
公開日2015-12-09
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.
Sci Rep, 5, 2015
2LS6
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Solution NMR Structure of a Non-canonical galactose-binding CBM32 from Clostridium perfringens
分子名称: Hyaluronoglucosaminidase
著者Grondin, J.M, Chitayat, S, Ficko-Blean, E, Boraston, A.B, Smith, S.P.
登録日2012-04-20
公開日2013-05-01
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.
J.Mol.Biol., 426, 2014
6OE2
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X-Ray Structure of the C-terminal domain (277-440) of Putative chitobiase from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium Target BtR324A. Re-refinement of 3GGL with correct metal Mn replacing Zn. New metal confirmed with PIXE analysis of original sample.
分子名称: Chitobiase, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION
著者Snell, E.H, Garman, E.F, Lowe, E.D.
登録日2019-03-27
公開日2019-12-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application.
J.Am.Chem.Soc., 142, 2020
8PFE
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Crystal Structure of an Hexavariant of the b1 Domain of Human Neuropilin-1 in Complex with the KDKPPR Peptide
分子名称: ACETATE ION, LYS-ASP-LYS-PRO-PRO-ARG, Neuropilin-1
著者Jelsch, C, Favier, F, Didierjean, C.
登録日2023-06-15
公開日2023-08-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand.
Molecules, 28, 2023
7RGA
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Crystal structure of nanoCLAMP3:VHH in complex with MTX
分子名称: METHOTREXATE, SODIUM ION, nano CLostridial Antibody Mimetic Protein 3 VHH
著者Guo, Z, Alexandrov, K.
登録日2021-07-14
公開日2022-05-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices.
Nat Commun, 12, 2021
9EOU
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Crystal Structure of the b1b2 domains from Human Neuropilin-1 in complex with a peptide.
分子名称: Neuropilin-1, Osteopontin
著者Caing-Carlsson, R, Duelli, A, Walse, B.
登録日2024-03-15
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis.
Pharmacol Res, 205, 2024
9D5D
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Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A
分子名称: Factor VIIIa light chain
著者Avery, N.G, Childers, K.C, Spiegel, P.C.
登録日2024-08-13
公開日2024-09-04
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces
To Be Published
4LKS
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Structure of CBM32-3 from a family 31 glycoside hydrolase from Clostridium perfringens in complex with galactose
分子名称: CALCIUM ION, Glycosyl hydrolase, family 31/fibronectin type III domain protein, ...
著者Grondin, J.M, Duan, D, Kirlin, A.C, Furness, H.S, Allingham, J.S, Smith, S.P.
登録日2013-07-08
公開日2014-12-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens.
Plos One, 12, 2017
4LPL
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BU of 4lpl by Molmil
Structure of CBM32-1 from a family 31 glycoside hydrolase from Clostridium perfringens
分子名称: CALCIUM ION, Glycosyl hydrolase, family 31/fibronectin type III domain protein, ...
著者Grondin, J.M, Duan, D, Heather, F.S, Spencer, C.A, Allingham, J.S, Smith, S.P.
登録日2013-07-16
公開日2014-07-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens.
Plos One, 12, 2017
2Z4F
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BU of 2z4f by Molmil
Solution structure of the Discoidin Domain of DDR2
分子名称: Discoidin domain-containing receptor 2
著者Ichikawa, O, Osawa, M, Nishida, N, Goshima, N, Nomura, N, Shimada, I.
登録日2007-06-16
公開日2007-09-04
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Structural basis of the collagen-binding mode of discoidin domain receptor 2
Embo J., 26, 2007
6FMC
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Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure
分子名称: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1
著者Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P.
登録日2018-01-30
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
5N6W
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BU of 5n6w by Molmil
Retinoschisin R141H Mutant
分子名称: Retinoschisin
著者Ramsay, E.P, Collins, R.F, Owens, T.W, Siebert, C.A, Jones, R.P.O, Roseman, A, Wang, T, Baldock, C.
登録日2017-02-16
公開日2017-04-12
最終更新日2017-08-30
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function
Human Molecular Genetics, 25, 2016
5IJR
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BU of 5ijr by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand.
分子名称: DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-03-02
公開日2017-03-29
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
6FMF
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BU of 6fmf by Molmil
Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure
分子名称: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid
著者Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P.
登録日2018-01-31
公開日2018-10-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.811 Å)
主引用文献Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
5IYY
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BU of 5iyy by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand.
分子名称: Neuropilin-1, N~2~-[(benzyloxy)carbonyl]-L-arginine
著者Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
登録日2016-03-24
公開日2017-04-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
4KI5
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BU of 4ki5 by Molmil
Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99
分子名称: Coagulation factor VIII, MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, ...
著者Walter, J.D, Meeks, S.L, Healey, J.F, Lollar, P, Spiegel, P.C.
登録日2013-05-01
公開日2014-01-15
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.
Blood, 122, 2013
5C7G
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BU of 5c7g by Molmil
Crystal Structure of the b1 Domain of Human Neuropilin-1 in complex with a bicine molecule
分子名称: BICINE, Neuropilin-1, SODIUM ION
著者Didierjean, C, Jelsch, C.
登録日2015-06-24
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Design, synthesis and biological evaluation of new peptidomimetic compounds targeting NRP-1 receptor TO BE PUBLISHED
To Be Published
7O1N
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Crystal Structure of Human Neuropilin-1 b1 Domain mutant - Y297A
分子名称: Neuropilin-1
著者Djordjevic, S, Chandanani, J, Faleeva, M, Pinotsis, N.
登録日2021-03-29
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal Structure of Human Neuropilin-1 b1 Domain mutant - Y297A
To Be Published
1IQD
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Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.
分子名称: HUMAN FACTOR VIII, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN
著者Spiegel Jr, P.C, Jacquemin, M, Saint-Remy, J.M, Stoddard, B.L, Pratt, K.P.
登録日2001-07-21
公開日2001-08-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.
Blood, 98, 2001
1TVG
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X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.
分子名称: CALCIUM ION, LOC51668 protein, SAMARIUM (III) ION
著者Kuzin, A.P, Vorobiev, S.M, Lee, I, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2004-06-29
公開日2004-11-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study.
Proteins, 75, 2009
7P5U
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Neuropilin-b1 in a complex with a VEGFB-derived peptide
分子名称: MGC0122, Neuropilin-1
著者Fotinou, C, Rhana, R, Yelland, T.
登録日2021-07-14
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Neuropilin-b1 in a complex with a VEGFB-derived peptide
To Be Published

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