2H7T
 
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8R6T
 | | NMR solution structure of thyropin IrThy-Cd from the hard tick Ixodes ricinus | | 分子名称: | Putative two thyropin protein (Fragment) | | 著者 | Srb, P, Veverka, V, Matouskova, Z, Orsaghova, K, Mares, M. | | 登録日 | 2023-11-23 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
Int J Mol Sci, 25, 2024
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1RMJ
 | | C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II | | 分子名称: | Insulin-like growth factor binding protein 6 | | 著者 | Headey, S.J, Keizer, D.W, Yao, S, Brasier, G, Kantharidis, P, Bach, L.A, Norton, R.S. | | 登録日 | 2003-11-28 | | 公開日 | 2004-09-14 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II.
Mol.Endocrinol., 18, 2004
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1L3H
 | | NMR structure of P41icf, a potent inhibitor of human cathepsin L | | 分子名称: | MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf) | | 著者 | Chiva, C, Barthe, P, Codina, A, Giralt, E. | | 登録日 | 2002-02-27 | | 公開日 | 2003-03-04 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Synthesis and NMR structure of P41ICF, a potent inhibitor of human cathepsin L
J.Am.Chem.Soc., 125, 2003
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1ZT3
 | | C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Insulin-like growth factor binding protein 1 | | 著者 | Sala, A, Capaldi, S, Campagnoli, M, Faggion, B, Labo, S, Perduca, M, Romano, A, Carrizo, M.E, Valli, M, Visai, L, Minchiotti, L, Galliano, M, Monaco, H.L. | | 登録日 | 2005-05-26 | | 公開日 | 2005-06-28 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and Properties of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-1 Isolated from Human Amniotic Fluid
J.Biol.Chem., 280, 2005
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1ZT5
 | | C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II) | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, FE (II) ION, Insulin-like growth factor binding protein 1 | | 著者 | Sala, A, Capaldi, S, Campagnoli, M, Faggion, B, Labo, S, Perduca, M, Romano, A, Carrizo, M.E, Valli, M, Visai, L, Minchiotti, L, Galliano, M, Monaco, H.L. | | 登録日 | 2005-05-26 | | 公開日 | 2005-06-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.818 Å) | | 主引用文献 | Structure and Properties of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-1 Isolated from Human Amniotic Fluid
J.Biol.Chem., 280, 2005
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6I07
 | | Crystal structure of EpCAM in complex with scFv | | 分子名称: | Epithelial cell adhesion molecule, GLYCEROL, Single chain Fv | | 著者 | Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G. | | 登録日 | 2018-10-25 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7QTQ
 | | Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ... | | 著者 | Marechal, N, Weitz, J.C, Serrano, B.P, Zhang, X. | | 登録日 | 2022-01-15 | | 公開日 | 2022-05-04 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Nat Commun, 13, 2022
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6SCJ
 | | The structure of human thyroglobulin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Coscia, F, Turk, D, Lowe, J. | | 登録日 | 2019-07-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The structure of human thyroglobulin.
Nature, 578, 2020
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4MZV
 | | Crystal structure of extracellular part of human EpCAM | | 分子名称: | DECYL-BETA-D-MALTOPYRANOSIDE, Epithelial cell adhesion molecule | | 著者 | Pavsic, M, Guncar, G, Djinovic-Carugo, K, Lenarcic, B. | | 登録日 | 2013-09-30 | | 公開日 | 2014-08-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.865 Å) | | 主引用文献 | Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.
Nat Commun, 5, 2014
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7N4Y
 | | The structure of bovine thyroglobulin with iodinated tyrosines | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kim, K, Clarke, O.B. | | 登録日 | 2021-06-04 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | The structure of natively iodinated bovine thyroglobulin.
Acta Crystallogr D Struct Biol, 77, 2021
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1ICF
 | | CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (CATHEPSIN L: HEAVY CHAIN), PROTEIN (CATHEPSIN L: LIGHT CHAIN), ... | | 著者 | Guncar, G, Pungercic, G, Klemencic, I, Turk, V, Turk, D. | | 登録日 | 1999-01-07 | | 公開日 | 2000-01-12 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.
EMBO J., 18, 1999
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7PEE
 | | Crystal structure of extracellular part of human Trop2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | | 著者 | Pavsic, M. | | 登録日 | 2021-08-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM.
Int J Mol Sci, 22, 2021
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6O0E
 | | Saxiphilin:STX complex, soaking | | 分子名称: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | 著者 | Yen, T.J, Lolicato, M, Minor, D.L. | | 登録日 | 2019-02-16 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
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7B75
 | | Cryo-EM Structure of Human Thyroglobulin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ... | | 著者 | Adaixo, R, Righetto, R, Steiner, E.M, Taylor, N.M.I, Stahlberg, H. | | 登録日 | 2020-12-09 | | 公開日 | 2021-12-29 | | 最終更新日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of native human thyroglobulin.
Nat Commun, 13, 2022
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6O0D
 | | Saxiphilin Apo structure | | 分子名称: | Saxiphilin | | 著者 | Yen, T.J, Lolicato, M, Minor, D.L. | | 登録日 | 2019-02-16 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
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6O0F
 | | Saxiphilin:STX complex, co-crystal | | 分子名称: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | 著者 | Yen, T.J, Lolicato, M, Minor, D.L. | | 登録日 | 2019-02-16 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
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7E5M
 | | crystal structure of trans assembled human TROP-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor-associated calcium signal transducer 2 | | 著者 | Sun, M, Zhang, H, Chai, Y, Qi, J, Gao, G.F, Tan, S. | | 登録日 | 2021-02-19 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.
Iscience, 24, 2021
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7E5N
 | | crystal structure of cis assembled TROP-2 | | 分子名称: | Tumor-associated calcium signal transducer 2 | | 著者 | Sun, M, Zhang, H, Chai, Y, Qi, J, Gao, G.F, Tan, S. | | 登録日 | 2021-02-19 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.
Iscience, 24, 2021
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8D6P
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8D6U
 | | Rana catesbeiana saxiphilin:F-STX (soaked) | | 分子名称: | (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, Saxiphilin | | 著者 | Chen, Z, Zakrzewska, S, Minor, D.L. | | 登録日 | 2022-06-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6S
 | | Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal) | | 分子名称: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | 著者 | Chen, Z, Zakrzewska, S, Minor, D.L. | | 登録日 | 2022-06-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6T
 | | Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal) | | 分子名称: | CACODYLATE ION, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | | 著者 | Chen, Z, Zakrzewska, S, Minor, D.L. | | 登録日 | 2022-06-06 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8D6Q
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7WRQ
 | | Structure of Human IGF1/IGFBP3/ALS Ternary Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... | | 著者 | Kim, H, Fu, Y, Kim, H.M. | | 登録日 | 2022-01-27 | | 公開日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Nat Commun, 13, 2022
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