9PTI
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6YHY
| A lid blocking mechanism of a cone snail toxin revealed at the atomic level | 分子名称: | Conk-S1 | 著者 | Saikia, C, Altman-Gueta, H, Dym, O, Frolow, F, Gurevitz, M, Gordon, D, Reuveny, E, Karbat, I. | 登録日 | 2020-03-31 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A Molecular Lid Mechanism of K + Channel Blocker Action Revealed by a Cone Peptide. J.Mol.Biol., 433, 2021
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6Q61
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | 分子名称: | Kunitz-type conkunitzin-S1, SULFATE ION | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | 登録日 | 2018-12-10 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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6Q6C
| Pore-modulating toxins exploit inherent slow inactivation to block K+ channels | 分子名称: | 1,2-ETHANEDIOL, Kunitz-type conkunitzin-S1, NITRATE ION, ... | 著者 | Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E. | 登録日 | 2018-12-10 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Pore-modulating toxins exploit inherent slow inactivation to block K+channels. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NAN
| NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition | 分子名称: | Ixolaris | 著者 | De Paula, V.S, Sgourakis, N.G, Francischetti, I.M.B, Almeida, F.C.L, Monteiro, R.Q, Valente, A.P. | 登録日 | 2018-12-06 | 公開日 | 2019-06-12 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition. Blood, 134, 2019
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5M4V
| X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor | 分子名称: | CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL | 著者 | Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N. | 登録日 | 2016-10-19 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8PTI
| CRYSTAL STRUCTURE OF A Y35G MUTANT OF BOVINE PANCREATIC TRYPSIN INHIBITOR | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR | 著者 | Housset, D, Kim, K.-S, Fuchs, J, Woodward, C, Wlodawer, A. | 登録日 | 1990-12-17 | 公開日 | 1991-04-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor. J.Mol.Biol., 220, 1991
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6F1F
| The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure | 分子名称: | GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION | 著者 | Lansky, S, Mousa, R, Metanis, N, Shoham, G. | 登録日 | 2017-11-21 | 公開日 | 2018-07-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.716 Å) | 主引用文献 | BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path. Chem Sci, 9, 2018
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6PTI
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5NMV
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6KZF
| Racemic X-ray Structure of Calcicludine | 分子名称: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | 著者 | Qu, Q, Gao, S, Liu, L. | 登録日 | 2019-09-24 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy Angew.Chem.Int.Ed.Engl., 59, 2020
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5EZD
| Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1 | 分子名称: | ACETATE ION, Kunitz-type protease inhibitor 1, POTASSIUM ION | 著者 | Hong, Z, Andreasen, P.A, Morth, J.P, Jensen, J.K. | 登録日 | 2015-11-26 | 公開日 | 2016-05-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J.Biol.Chem., 291, 2016
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2ZJX
| Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | 著者 | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | 登録日 | 2008-03-11 | 公開日 | 2008-10-21 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Crystal structure of an extensively simplified variant of bovine pancreatic trypsin inhibitor in which over one-third of the residues are alanines Proc.Natl.Acad.Sci.Usa, 105, 2008
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2ZVX
| Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | 著者 | Islam, M.M, Sohya, S, Noguchi, K, Yohda, M, Kuroda, Y. | 登録日 | 2008-11-24 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations Proteins, 77, 2009
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5PTI
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1AAL
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1AAP
| X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | 分子名称: | ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN | 著者 | Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A. | 登録日 | 1990-09-14 | 公開日 | 1991-10-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry, 29, 1990
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1ADZ
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1B0C
| EVIDENCE OF A COMMON DECAMER IN THREE CRYSTAL STRUCTURES OF BPTI, CRYSTALLIZED FROM THIOCYANATE, CHLORIDE OR SULFATE | 分子名称: | PROTEIN (PANCREATIC TRYPSIN INHIBITOR) | 著者 | Hamiaux, C, Prange, T, Ries-Kautt, M, Ducruix, A, Lafont, S, Astier, J.P, Veesler, S. | 登録日 | 1998-11-06 | 公開日 | 1998-11-11 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The BPTI decamer observed in acidic pH crystal forms pre-exists as a stable species in solution. J.Mol.Biol., 297, 2000
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4PTI
| THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | 分子名称: | TRYPSIN INHIBITOR | 著者 | Huber, R, Kukla, D, Ruehlmann, A, Epp, O, Formanek, H, Deisenhofer, J, Steigemann, W. | 登録日 | 1982-09-27 | 公開日 | 1983-01-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983
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3LDI
| Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | 分子名称: | GLYCEROL, MERCURY (II) ION, Pancreatic trypsin inhibitor, ... | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | 登録日 | 2010-01-13 | 公開日 | 2010-06-23 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding Biochem.Biophys.Res.Commun., 397, 2010
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3LDJ
| Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, Pancreatic trypsin inhibitor | 著者 | Yang, I.S, Kim, T.G, Park, B.S, Kim, K.H. | 登録日 | 2010-01-13 | 公開日 | 2010-09-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding. Biochem.Biophys.Res.Commun., 2010
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4BQD
| KD1 of human TFPI in complex with a synthetic peptide | 分子名称: | GLYCEROL, PEPTIDE, TISSUE FACTOR PATHWAY INHIBITOR (LIPOPROTEIN-ASSOCIATED COAGULATION INHIBITOR) VARIANT | 著者 | Griessner, A, Brandstetter, H. | 登録日 | 2013-05-30 | 公開日 | 2013-12-04 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor Viia by Tissue Factor Pathway Inhibitor (Tfpi) J.Biol.Chem., 289, 2014
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2CA7
| Conkunitzin-S1 Is The First Member Of A New Kunitz-Type Neurotoxin Family- Structural and Functional Characterization | 分子名称: | CONKUNITZIN-S1 | 著者 | Bayrhuber, M, Vijayan, V, Ferber, M, Graf, R, Korukottu, J, Imperial, J, Garrett, J.E, Olivera, B.M, Terlau, H, Zweckstetter, M, Becker, S. | 登録日 | 2005-12-19 | 公開日 | 2006-01-05 | 最終更新日 | 2020-01-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem., 280, 2005
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4DTG
| Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Humanized recombinant FAB fragment, ... | 著者 | Svensson, L.A, Breinholt, J, Krogh, B.O, Hilden, I. | 登録日 | 2012-02-21 | 公開日 | 2012-06-13 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model. Blood, 119, 2012
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