5NMV

Crystal structure of 2F22 Fab fragment against TFPI1

Summary for 5NMV

• Entry DOI: 10.2210/pdb5nmv/pdb
• Descriptor: Fab light chain, Fab heavy chain, Tissue factor pathway inhibitor, ... (5 entities in total)
• Functional Keywords: fab, immune system
• Biological source: Mus; More
• Cellular location: Isoform Alpha: Secreted. Isoform Beta: Microsome membrane ; Lipid-anchor, GPI-anchor : P10646
• Total number of polymer chains: 3
• Total formula weight: 57223.83

Authors

Svensson, L.A.,Petersen, H.H. (deposition date: 2017-04-07, release date: 2018-03-28, Last modification date: 2018-05-09)

• Primary citation: Augustsson, C.,Svensson, A.,Kjaer, B.,Chao, T.Y.,Wenjuan, X.,Krogh, B.O.,Breinholt, J.,Clausen, J.T.,Hilden, I.,Petersen, H.H.,Petersen, L.C.; Factor Xa and VIIa inhibition by tissue factor pathway inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain.; J. Thromb. Haemost., 16:893-904, 2018; PubMed: 29532595; DOI: 10.1111/jth.14000

Experimental method

X-RAY DIFFRACTION (1.65 Å)