5NMV

Crystal structure of 2F22 Fab fragment against TFPI1

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GOL L 301

Chain	Residue
H	PHE174
L	SER176
L	THR177
L	HOH422
H	PRO175
H	VAL177
H	SER185
H	LEU186
H	SER187
L	GLN159
L	SER161
L	SER175

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL L 302

Chain	Residue
H	ILE92
L	GLN38
L	PRO40
L	GLY41
L	GLN42

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL H 301

Chain	Residue
H	ASP109
H	HOH437
H	HOH568
K	ILE46
K	ARG49
L	LYS45
L	LEU46

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site_id	AC4
Number of Residues	8
Details	binding site for residue GOL H 302

Chain	Residue
H	LYS43
H	GLY44
H	LEU45
H	HOH476
L	PHE97
L	GLY98
L	GLY99
L	HOH494

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Functional Information from PROSITE/UniProt

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FiyGGCegnqnrFesleeC

Chain	Residue	Details
K	PHE54-CYS72

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
H	TYR202-HIS208
L	TYR191-HIS197

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Reactive bond

Chain	Residue	Details
K	LYS36

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:19017259

Chain	Residue	Details
K	THR14

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