5NMV
Crystal structure of 2F22 Fab fragment against TFPI1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Fab light chain | polymer | 213 | 23242.8 | 1 | Mus | ||
| 2 | B (H) | Fab heavy chain | polymer | 222 | 23814.7 | 1 | Mus | ||
| 3 | C (K) | Tissue factor pathway inhibitor | polymer | 86 | 9797.9 | 1 | UniProt (P10646) Pfam (PF00014) | Homo sapiens (Human) | TFPI,Extrinsic pathway inhibitor,EPI,Lipoprotein-associated coagulation inhibitor,LACI |
| 4 | D, E, F, G (L, H) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | H, I, J (L, H, K) | water | water | 18.0 | 489 | Chemie (HOH) |
Sequence modifications
K: 1 - 79 (UniProt: P10646)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 56855.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 57223.8 |
