6NAN
NMR structure determination of Ixolaris and Factor X interaction reveals a noncanonical mechanism of Kunitz inhibition
Summary for 6NAN
| Entry DOI | 10.2210/pdb6nan/pdb |
| NMR Information | BMRB: 27051 |
| Descriptor | Ixolaris (1 entity in total) |
| Functional Keywords | coagulation blood inhibitor, factor xa, tissue factor, tick saliva, blood clotting |
| Biological source | Ixodes scapularis (Black-legged tick) |
| Total number of polymer chains | 1 |
| Total formula weight | 15753.25 |
| Authors | De Paula, V.S.,Sgourakis, N.G.,Francischetti, I.M.B.,Almeida, F.C.L.,Monteiro, R.Q.,Valente, A.P. (deposition date: 2018-12-06, release date: 2019-06-12, Last modification date: 2023-06-14) |
| Primary citation | De Paula, V.S.,Sgourakis, N.G.,Francischetti, I.M.B.,Almeida, F.C.L.,Monteiro, R.Q.,Valente, A.P. NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition. Blood, 134:699-708, 2019 Cited by PubMed: 31133602DOI: 10.1182/blood.2018889493 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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